Oro-facial manifestations, oxidative stress marker and antioxidant in serum and saliva of patients with beta thalassemia major

Joint Authors

Shamsah, Muaid S. Abbas
Zaidan, Taghrid Fadil

Source

Journal of Baghdad College of Dentistry

Issue

Vol. 27, Issue 2 (30 Jun. 2015), pp.93-97, 5 p.

Publisher

University of Baghdad College of Dentistry

Publication Date

2015-06-30

Country of Publication

Iraq

No. of Pages

5

Main Subjects

Medicine

Topics

Abstract AR

الثلاسيميا بيتا هو نموذج من مرض وراثي من فقر الدم الشديد و الذي كان سببه وجود خلل في نوعين من البروتين (ألفا و بيتا) من مكونات الهيموغلوبين.

الشد التأكسدي هو اختلا التوازن بين حالة الأكسدة / مضادات الأكسدة في النظام الخلوي مما يؤدي إلى اتلاف الخلايا.

مضادات الأكسدة هي مواد كيميائية تؤخر بدء أو تبطئ معدل معدل تفاعل أكسدة الدهون و أنها تلعب دوراً مهماً في نظام دفاع الجسم ضد أنواع الأوكسجينات التفاعلية.

كانت أهداف هذه الدراسة هي تسجيل الظواهر الوجهية و الفموية لمرضى البيتا ثلاسيميا و تقييم عامل الأكسدة malondialdehyde و دوره في مرض بيتا ثلاسيميا و تقييم مضادات الأكسدة حامض اليوريك في دم و لعاب هؤلاء المرضى.

Abstract EN

Background: Beta thalassemia is a typically autosomal recessive form of severe anemia which is caused by an imbalance of two types of protein (alpha and beta) subunits of hemoglobin.

Oxidative stress imbalance is the equilibrium between pro-oxidant\antioxidant statuses in cellular system, which results in damaging the cells.

Antioxidant is a chemical that delays the start or slows the rate of lipid oxidation reaction and it play a very important role in the body defense system against reactive oxygen species.

The aims of this study were to recorded the orofacial manifestations in beta thalassemic patients and assess the oxidative stress marker malondialdehyde in serum and salivs and their role in the pathogenesis of beta thalassemia and evaluation the antioxidant uric acid in serum and saliva of those patients.

Methods: The study included fifty eight beta thalassemic major patients, twenty eight patients with periodontitis and thirty patients without periodontitis and twenty nine healthy subjects that were age matched with the patients.

Orofacial manifestations recorded clinically, serum and saliva malondialdehyde and uric acid were measured in all subjects.

Results : The main oro-facial manifestations were malocclusion ,rodent face, brown pigmentation of oral mucosa and incompetent lip.The mean serum and saliva malondialdehyde was significantly higher in thalassemic patients with periodontitis (p<0.001).

Serum and saliva uric acid was significantly higher in thalassemic patients without periodontitis (p<0.001).

Conclusions: Malocclusion was the most prevalent oro-facial manifestations in beta thalassemic patients, increased serum and saliva malondialdehde refer to the role of oxidative stress in the pathogenesis of beta thalassemia.

Uric acid increased to counteract the elevation in the oxidative stress process.

American Psychological Association (APA)

Shamsah, Muaid S. Abbas& Zaidan, Taghrid Fadil. 2015. Oro-facial manifestations, oxidative stress marker and antioxidant in serum and saliva of patients with beta thalassemia major. Journal of Baghdad College of Dentistry،Vol. 27, no. 2, pp.93-97.
https://search.emarefa.net/detail/BIM-590793

Modern Language Association (MLA)

Shamsah, Muaid S. Abbas& Zaidan, Taghrid Fadil. Oro-facial manifestations, oxidative stress marker and antioxidant in serum and saliva of patients with beta thalassemia major. Journal of Baghdad College of Dentistry Vol. 27, no. 2 (Jun. 2015), pp.93-97.
https://search.emarefa.net/detail/BIM-590793

American Medical Association (AMA)

Shamsah, Muaid S. Abbas& Zaidan, Taghrid Fadil. Oro-facial manifestations, oxidative stress marker and antioxidant in serum and saliva of patients with beta thalassemia major. Journal of Baghdad College of Dentistry. 2015. Vol. 27, no. 2, pp.93-97.
https://search.emarefa.net/detail/BIM-590793

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 96-97

Record ID

BIM-590793