Evaluation of some chelating agents efficacy in treatment of lead toxicity : haematological, biochemical and histopathological studies
Other Title(s)
تقييم كفاءة بعض المنتجات في علاج التسمم بالرصاص : دراسات دموية و بيوكيميائية و هستوباثولوجية
Joint Authors
Salim, Dayfi Ahmad
Sharqawi, Ahmad Abd al-Baqi
Shihatah, Umar Adil
al-Sayyid, Manal Muhammad Ahmad
Source
Assiut Veterinary Medical Journal
Issue
Vol. 60, Issue 142 (30 Sep. 2014), pp.160-171, 12 p.
Publisher
Assiut University Faculty of Veterinary Medicine
Publication Date
2014-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract AR
تعد الملوثات البیئیة (خاصة المعدنیة منھا) مثار اھتمام العالم الیوم و مستقبلا، لخطورتھا على صحة الإنسان و الحیوان و یؤدى تعرض الحیوان لھذه الملوثات لمشكلات صحیة تؤثر على إنتاجية و كذلك انتقال ھذه الملوثات من خلال ھذه المنتجات إلى الإنسان مما یعتبر بالإضافة إلى البيئة المحیطھ (ھواء، ماء، نباتات).
تم فى ھذه الدراسة استخدام مائة و عشرون من الجرذان مصدرا مباشرا للتلوث كضابط للتجربة و الثانیة و الثالثة و الرابعةً C البیضاء قسمت إلى أربع مجموعات كل منھا ثلاثون جرذا استخدمت المجموعة الأولى (4, 3 and 2) تعرضت لخلات الرصاص في ماء الشرب لمده ١٢ أسبوعا, و تم علاج المجموعتین (4, 3) بمركبات DMSA و DMPS على التوالي بعد ١٢ ،١٠ ،٨ ،٦ ،٤ ،٢ أسبوع و تم اخذ العینات للفحص بعد ٢٤ ساعة من العلاج لقیاس كل من صورة الدم والمؤثرات البیوكیمیائیھ (الخمائر الكبدیة AST, ALT and γ–GT).
و تم تسجیل التغیرات الھستوباثولوجیة في أنسجة الكبد و الكلى و المخ.
و أظھرت نتائج ھذه الدراسة.ً DMPS ً أخذا في الاعتبار نتائج عدد كرات الدم الحمراء و الھیموجلوبین (١) أن DMSA أكثر تأثيرا كتریاق عن (٢) أن DMPS أكثر تأثيرا على عدد كرات الدم البیضاء.
(3) كلا المركبین اظھر نفس التاثیر على الإنزیمات التي تم قیاسھا .( AST, ALT & γ-GT) ٤) أظھرت نتائج التغییرات الھستوباثولوجیة فى المجموعات الثلاث مقارنة بالمجموعات المستخدمة كضابط للتجربة وجود فرق واضح بین المجموعة (D) و كلا من المجموعتین (4(2& حیث أدى العلاج بمركب DMSA إلى تخفیف بعض الإصابات الباثولوجیة في كل من الكبد والكلى والمخ مقارنة بكلتا المجموعتین ٤ ، ٢.
Abstract EN
The aim of the study was to evaluate efficacy of DMSA and DMPS in treatment of lead toxicity in albino rats.
One hundred twenty male albino rats were divided into four groups (30 each).
The first was used as control, the 2nd group was exposed to lead acetate in drinking water (100 ppm) for 12 weeks, the 3rd group was exposed to lead acetate as in 2nd group together with DMSA (135 mg/kg bworally by intubation) and the 4th group was exposed to lead acetate as in 2nd group together with DMPS (200 mumol/kg bw IP).
The result revealed that the RBCs count showed a significant decrease in 2nd group while in 3rd and 4th was recorded in the last 10th and 12th weeks.
The mean corpuscular volume (MCV) showed a significant decrease at the 6th - 12th week in 2nd, 3rd and 4th groups haematocrit percent (%) showed significant decrease in 2nd & 4th groups all over the study and in 6th, 8th, 10th and 12th weeks in 3rd group.
Haemoglobin level showed a significant decrease in 2nd and in 8th, 10th and 12th weeks in 4th and only at 12th in 3rd.
A significant decrease in MCH values was recorded 2nd, 3rd and 4th groups.
WBCs count showed a significant increase in 2nd, 4th weeks in group 2nd and 3rd while decreased at 10th & 12th weeks.
In 4th group, a significant decrease was noticed at 6th, 8th, 10th and 12th weeks.
Serum AST and ALT showed a significant decrease at the 12th week in 2nd and increase at the 2nd week in both 3rd and 4th.
Gamma-GT showed no significant change in 2nd in comparison with group 1.
A significant decrease in 3rd and 4th was recorded at the 2nd, 4th, and 6th weeks in comparison with 1st & 2nd.
The histopathological examination revealed a clear variance between group 2nd, 3rd and 4th.
Most of the recorded lesions in the liver, kidney and brain of 2nd & 4th groups at severe or moderate degree were absent or in a mild form in group 3rd.
In conlusion the two chelating agents (DMSA & DMPS) used run in nearly similar manner as every one has special advantages in treatment.
American Psychological Association (APA)
Salim, Dayfi Ahmad& Sharqawi, Ahmad Abd al-Baqi& al-Sayyid, Manal Muhammad Ahmad& Shihatah, Umar Adil. 2014. Evaluation of some chelating agents efficacy in treatment of lead toxicity : haematological, biochemical and histopathological studies. Assiut Veterinary Medical Journal،Vol. 60, no. 142, pp.160-171.
https://search.emarefa.net/detail/BIM-591393
Modern Language Association (MLA)
Salim, Dayfi Ahmad…[et al.]. Evaluation of some chelating agents efficacy in treatment of lead toxicity : haematological, biochemical and histopathological studies. Assiut Veterinary Medical Journal Vol. 60, no. 142 (Sep. 2014), pp.160-171.
https://search.emarefa.net/detail/BIM-591393
American Medical Association (AMA)
Salim, Dayfi Ahmad& Sharqawi, Ahmad Abd al-Baqi& al-Sayyid, Manal Muhammad Ahmad& Shihatah, Umar Adil. Evaluation of some chelating agents efficacy in treatment of lead toxicity : haematological, biochemical and histopathological studies. Assiut Veterinary Medical Journal. 2014. Vol. 60, no. 142, pp.160-171.
https://search.emarefa.net/detail/BIM-591393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 170-171
Record ID
BIM-591393
