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Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy
Joint Authors
Pradhan, Subal Kumar
Sivaraj, Pradeep
Das, Lina
Swain, Arakhita
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 4 (31 Aug. 2015), pp.708-711, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-08-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Children
- Kidneys
- Diseases
- Spectrometers
- Optics
- Light
- Analytical chemistry
- Therapeutics
- Biopsy
- IgA glomerulonephritis
- Anatomical pathology
- Absorption spectra
Abstract EN
Immunoglobulin A nephropathy (IgAN) is one of the most common types of primary glomerulonephritis in the world.
Nephrotic syndrome is an uncommon presentation of IgAN.
To evaluate the clinico-pathological features and treatment response of nephrotic IgAN, we prospectively studied 20 nephrotic children with biopsy-proven IgAN at our center from August 2009 to December 2012.
The histopathological characterization of IgAN was carried out with the HAAS classification.
The demographic profile, clinical presentation, initial laboratory, biopsy findings and treatment response were analyzed.
The mean age was 6.7 years.
The most common indication of renal biopsy was steroid-dependent nephrotic syndrome associated with microscopic hematuria (65%) and hypertension (25%).
The majority of cases were classified as HAAS-III stage.
Fifteen cases responded to oral cyclosporine-A, four cases to oral cyclophosphamide and one to mycophenolate mofetil.
Complete remission of the nephrotic syndrome was achieved in 90% (18/20) cases within 3 months of initiation of therapy.
Two cases that had partial remission were in the HASS-II and III stages.
We conclude that the majority of children with nephrotic IgAN responded to oral cyclosporine-A.
However, a larger cohort and longer duration follow-up are required to confirm our results.
American Psychological Association (APA)
Pradhan, Subal Kumar& Sivaraj, Pradeep& Das, Lina& Swain, Arakhita. 2015. Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 4, pp.708-711.
https://search.emarefa.net/detail/BIM-592698
Modern Language Association (MLA)
Pradhan, Subal Kumar…[et al.]. Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 4 (Jul. / Aug. 2015), pp.708-711.
https://search.emarefa.net/detail/BIM-592698
American Medical Association (AMA)
Pradhan, Subal Kumar& Sivaraj, Pradeep& Das, Lina& Swain, Arakhita. Spectrum of clinico-pathological profile and treatment response in children with nephrotic immunoglobulin a nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 4, pp.708-711.
https://search.emarefa.net/detail/BIM-592698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 711
Record ID
BIM-592698