Hemodiafiltration using pre-dilutional On-Line citrate dialysate : a new technique for regional citrate anticoagulation : a feasibility study

Joint Authors

Bousselmi, Radwan
Hajjej, Ziyad
al-Liban, Ihab
al-Farjani, Mustafa
Baffoun, Anis
Bin Salih, Muhammad
Hamidah, Muhammad Jalil

Source

Saudi Journal of Kidney Diseases and Transplantation

Issue

Vol. 26, Issue 4 (31 Aug. 2015), pp.739-742, 4 p.

Publisher

Saudi Center for Organ Transplantation

Publication Date

2015-08-31

Country of Publication

Saudi Arabia

No. of Pages

4

Main Subjects

Medicine

Topics

Abstract EN

A prospective, observational, feasibility study was carried out on four patients with end-stage renal failure undergoing bicarbonate hemodialysis to study the feasibility of an on-line hemodiafiltration technique using a citrate dialysate with pre-dilutional infusion of citrate as a technique for regional citrate anticoagulation.

All patients had contraindication to systemic heparin anticoagulation.

The dialysis technique consisted of an on-line hemodiafiltration with a citrate dialysate without calcium using a Fresenius 4008S dialysis machine and Fresenius Polysulfone F60 dialyzers.

The infusion solution was procured directly from the dialysate and was infused into the arterial line.

To avoid the risk of hypocalcemia, calcium gluconate was infused to the venous return line.

The study was carried out in two stages.

During the first stage, the citrate infusion rate was 80 mL/min and the calcium infusion rate was 9 mmol/h.

At the second stage, the rates were 100 mL/min and 11 mmol/h, respectively.

The primary endpoint of this study was the incidence of thrombosis in the extracorporeal blood circuit and/or the dialyzer.

A total of 78 sessions were conducted.

All the sessions were well tolerated clinically and there were no major incidents in any of the four patients.

At the first stage of the study, there were five incidences of small clots in the venous blood chamber, an incidence of extracorporeal blood circuit thrombosis of 12.5%.

At the second stage of the study, no cases of extracorporeal blood circuit or dialyzer thrombosis were noted.

Hemodiafiltration with on-line citrate dialysate infusion to the arterial line is safe and allows an effective regional anticoagulation of the extracorporeal blood circuit without the need for systemic anticoagulation.

American Psychological Association (APA)

Bousselmi, Radwan& Baffoun, Anis& Hajjej, Ziyad& Bin Salih, Muhammad& al-Liban, Ihab& al-Farjani, Mustafa…[et al.]. 2015. Hemodiafiltration using pre-dilutional On-Line citrate dialysate : a new technique for regional citrate anticoagulation : a feasibility study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 4, pp.739-742.
https://search.emarefa.net/detail/BIM-592751

Modern Language Association (MLA)

Bousselmi, Radwan…[et al.]. Hemodiafiltration using pre-dilutional On-Line citrate dialysate : a new technique for regional citrate anticoagulation : a feasibility study. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 4 (Jul. / Aug. 2015), pp.739-742.
https://search.emarefa.net/detail/BIM-592751

American Medical Association (AMA)

Bousselmi, Radwan& Baffoun, Anis& Hajjej, Ziyad& Bin Salih, Muhammad& al-Liban, Ihab& al-Farjani, Mustafa…[et al.]. Hemodiafiltration using pre-dilutional On-Line citrate dialysate : a new technique for regional citrate anticoagulation : a feasibility study. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 4, pp.739-742.
https://search.emarefa.net/detail/BIM-592751

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 742

Record ID

BIM-592751