Pattern of glomerular disease in Nepal : a single-center experience
Joint Authors
Hada, Renu
Agrawal, R. K.
Khakurel, Sudha
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 4 (31 Aug. 2015), pp.833-838, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-08-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Glomerulonephritis (GN) is the most common cause of end-stage renal disease in Nepal.
The aim of the present study is to determine the clinical presentation and histological pattern of GN with and without immunofluorescence (IF).
It is a retrospective analysis of all GN patients with kidney biopsy at the Bir Hospital from January 2000 to April 2009.
The clinical presentation, blood pressure, urine analysis, 24-h urinary protein, biochemistry, hemoglobin, antinuclear antibody, anti-ds DNA, light microscopy (LM) and IF findings of kidney biopsies were computed from hospital records.
SPSS package was used for analysis.
A total of 398 patients [LM 204 (51%) and LM plus IF 194 (49%)] were analyzed.
The mean age of the study patients was 28 ± 13.6 years (range 7–74); males comprised 52.8% and females 47.2% of the patients; 51% were between 16 and 30 years of age.
The common clinical presentations included nephrotic syndrome (NS), seen in 69% of the patients, followed by acute nephritic syndrome, seen in 14.4% of the patients.
Kidney biopsy without IF showed mesangial proliferative GN (MesPGN) in 21.1%, membranoproliferative GN (MPGN) in 18.6%, membranous nephropathy (MN) in 14.2%, minimal change disease (MCD) in 12.3% and focal and segmental glomerulosclerosis (FSGS) in 9.8% of the cases.
With IF, MCD was seen in 23.2%, FSGS in 18%, MN in 11.9%, IgA nephropathy in 9.8%, MesPGN in 8.2%, MPGN in 4.1% and crescentic GN in 3.1% of the cases.
Lupus nephritis in the cases GN was most common in young adults, with the majority presenting with NS.
MCD and FSGS were the most common glomerular lesions; over-diagnosis of MesPGN and MPGN by LM could be due to exclusion of IgA nephropathy.
American Psychological Association (APA)
Khakurel, Sudha& Agrawal, R. K.& Hada, Renu. 2015. Pattern of glomerular disease in Nepal : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 4, pp.833-838.
https://search.emarefa.net/detail/BIM-593176
Modern Language Association (MLA)
Khakurel, Sudha…[et al.]. Pattern of glomerular disease in Nepal : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 4 (Jul. / Aug. 2015), pp.833-838.
https://search.emarefa.net/detail/BIM-593176
American Medical Association (AMA)
Khakurel, Sudha& Agrawal, R. K.& Hada, Renu. Pattern of glomerular disease in Nepal : a single-center experience. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 4, pp.833-838.
https://search.emarefa.net/detail/BIM-593176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 838
Record ID
BIM-593176