Batch and flow injection spectrophotometric determination of tetracycline hydrochloride and doxycycline hyclate in pharmaceutical preparations
Other Title(s)
التقدير الطيفي للتتراسايكلين هيدرو كلورايد و الددوكسي سايكلين هايكلات في المستحضرات الصيدلانية بطريقة الدفعة و الحقن الجرياني
Joint Authors
al-Nadawi, Ziyad Abd al-Sattar
al-Abaji, Muayyad Qasim Yasin
Source
Issue
Vol. 56, Issue 2A (31 Mar. 2015), pp.909-920, 12 p.
Publisher
University of Baghdad College of Science
Publication Date
2015-03-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
New, simple and accurate batch and flow injection spectrophotometric methods have been developed for the determinationsof tetracycline hydrochloride (TCH) and doxycycline hyclate (DCH) in pharmaceutical preparations.
The methods are based on diazotization of metchlopramide and coupling reaction with either TCH or DCH in alkaline medium to form yellow–orange water soluble dye with absorption maxima at 414 and 436 nm for TCH and DCH, respectively.
A graphs of absorbance versus concentration show that Beer’s law was obeyed over the concentration ranges of 1 –52 μgmL-1 TCH and DCH for batch method and of 8 – 240 μg mL-1 TCH and 5 – 350 μgmL-1 DCH for FIA method.
The limits of detection in batchmethods were 0.333 and 0.235μgmL-1for TCH and DCH respectively, and in FIA methods were 0.895, 0.612 μgmL-1for TCH and DCH respectively.
Samplethroughputs in FIA procedures were 120 and 80samples per hour for TCH and DCH, respectively.
Different chemical and physical experimental parameters affecting on the development and stability of the colored product were carefully studied and the proposed methods were successfully applied for determination of TCH and DCH in pharmaceutical preparations.
American Psychological Association (APA)
al-Abaji, Muayyad Qasim Yasin& al-Nadawi, Ziyad Abd al-Sattar. 2015. Batch and flow injection spectrophotometric determination of tetracycline hydrochloride and doxycycline hyclate in pharmaceutical preparations. Iraqi Journal of Science،Vol. 56, no. 2A, pp.909-920.
https://search.emarefa.net/detail/BIM-593500
Modern Language Association (MLA)
al-Abaji, Muayyad Qasim Yasin& al-Nadawi, Ziyad Abd al-Sattar. Batch and flow injection spectrophotometric determination of tetracycline hydrochloride and doxycycline hyclate in pharmaceutical preparations. Iraqi Journal of Science Vol. 56, no. 2A (2015), pp.909-920.
https://search.emarefa.net/detail/BIM-593500
American Medical Association (AMA)
al-Abaji, Muayyad Qasim Yasin& al-Nadawi, Ziyad Abd al-Sattar. Batch and flow injection spectrophotometric determination of tetracycline hydrochloride and doxycycline hyclate in pharmaceutical preparations. Iraqi Journal of Science. 2015. Vol. 56, no. 2A, pp.909-920.
https://search.emarefa.net/detail/BIM-593500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 919-920
Record ID
BIM-593500