Biochemical evaluation of metabolically active urinary stones

Abstract EN

The current study had been conducted to assess the clinical significance of lipid peroxidation (malondialdehyde (MDA) concentration), (total antioxidant capacity (TAC) and superoxide dismutase (SOD), and biochemical test of [urea, creatinine (Cr), uric acid (U.A), calcium (Ca +2), potassium (K +), sodium (Na +), phosphorus (PO4 -2)] in serum of urinary stone patients and also assess biochemical test of [urea, creatinine (Cr), uric acid (U.A), calcium (Ca +2), potassium (K +), sodium (Na +), phosphorus ((PO4 -2) and pH] in 24 hour urine sample.

Sixty patients with metabolic active urinary stones had been admitted to AL-Hilla Teaching Hospital, Urology Department during the period of November 2013 to April 2014.

All patients underwent full history and physical examination including: age, gender, family history of urolithiasis, past history of recurrent stone and any current medical diseases.

The urinary stones group composed of sixty patients (48 male and 12 female), the control group includes apparently healthy individuals (18 males and 12) females.

A highest occurrence of urinary stones is in the age 31-40 years.

The results of the present study showed non-significant difference in urea and Cr and the result showed a significantly increase in U.A.

Also the study showed a significant increase in the level of Ca+2 and non-significant in the level of Na and K and a significant decrease in the level of PO4 -2 .This study showed significant increase in MDA concentration and significant decrease in TAC and SOD , however showed significant increase in concentration of urea.

Cr, U.A, pH, Na; and decrease in the level of Ca +2 and P and non-significant in level of K in 24 hour urine in the urinary stones group compared to the control group.

In conclusion, urinary stone disease is affected by lipid peroxidation and antioxidant enzyme