One-pot synthesis, characterization and antimicrobial activity of new 3-cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)‎-2(1H)‎-pyridones

Abstract EN

The one-pot synthesis of new derivatives of 2(1H)-pyridone heterocycles carrying a thiophene nucleus is described.

The reactions were carried out via the condensation of 3-acetyl-2,5-dichlorothiophene and different alkyl aldehydes 2a-f with ethyl cyanoacetate in presence of ammonium acetate.

The pyridone derivatives 3a-f were obtained in 63-86 % yields and short reaction times.

The antimicrobial activities of the new compounds were evaluated against some common Gram negative and Gram positive bacteria and fungi.