One-pot synthesis, characterization and antimicrobial activity of new 3-cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)-2(1H)-pyridones
Author
Source
Issue
Vol. 10, Issue 2 (30 Jun. 2015), pp.98-107, 10 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2015-06-30
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Abstract EN
The one-pot synthesis of new derivatives of 2(1H)-pyridone heterocycles carrying a thiophene nucleus is described.
The reactions were carried out via the condensation of 3-acetyl-2,5-dichlorothiophene and different alkyl aldehydes 2a-f with ethyl cyanoacetate in presence of ammonium acetate.
The pyridone derivatives 3a-f were obtained in 63-86 % yields and short reaction times.
The antimicrobial activities of the new compounds were evaluated against some common Gram negative and Gram positive bacteria and fungi.
American Psychological Association (APA)
Ibrahim, Muhammad M.. 2015. One-pot synthesis, characterization and antimicrobial activity of new 3-cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)-2(1H)-pyridones. Jordan Journal of Chemistry،Vol. 10, no. 2, pp.98-107.
https://search.emarefa.net/detail/BIM-593845
Modern Language Association (MLA)
Ibrahim, Muhammad M.. One-pot synthesis, characterization and antimicrobial activity of new 3-cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)-2(1H)-pyridones. Jordan Journal of Chemistry Vol. 10, no. 2 (Jun. 2015), pp.98-107.
https://search.emarefa.net/detail/BIM-593845
American Medical Association (AMA)
Ibrahim, Muhammad M.. One-pot synthesis, characterization and antimicrobial activity of new 3-cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)-2(1H)-pyridones. Jordan Journal of Chemistry. 2015. Vol. 10, no. 2, pp.98-107.
https://search.emarefa.net/detail/BIM-593845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 105-107
Record ID
BIM-593845