Relation of antimullarian hormone with other hormones in women with polycystic ovary syndrome

Abstract AR

Polycystic ovary syndrome (PCOS) is very common endocrinological disorder in premenapusal women.

Anti-Mullerian hormone (AMH) is considered a local growth factor and a cellular differentiation factor.

In females, AMH is mainly secreted exclusively by the granulosa cells of ovarian early developing follicles.

In the present study, the relationships between AMH and different hormones were studied in PCOS women.

Sixty PCOS women patients were participated in the study in addition to 30 healthy women as control group.

Serum hormones (LH, FSH, testosterone, E2, progesterone (PRG), cortisol, Prolactine (PRL)) were measured using ready for use ELISA kits.

The results showed a significant higher Antimullarian hormone (AMH) level in PCOS patients as compared with healthy control group.

The results revealed a mild correlation between serum AMH with serum cortisol (r=0.327, p=0.011) and testosterone (r=0.390, p=0.008), respectively.

The results of the present study concluded that the AMH level is higher in PCOS in comparing with control group.

The correlation study between AMH and every measured parameter in PCOS patients showed that AMH are negatively correlated with age, and directly correlated with serum cortisol and testosterone.

These three parameters are the most effective parameters affecting the level of AMH in PCOS patients.

The present study spot the light on the role of cortisol and subsequently adrenal cortex activity in the PCOS women.