Evaluation of antimicrobial activity of prymidine dervative of some bacteria pathogens from urinary tract

Abstract AR

The current the study is carried out investigate of antimicrobial activity of uracil isophenol compound against some bacteria pathogens causing UTI infection .

The urine sample were collecting to hospitals in Najaf of (AL Sadr Medical City ) for the period from (2 in July 2013 to 2 in September 2013 up) The results were as follows: The proportion of isolated bacteria is E.coli 40% higher and the proportion of bacteria isolated is Staphylococcus aureus 32% and isolation of bacteria Pseudomonas.aeruginosa 28% in addition to some of the genera were diagnosed.

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In the course of the program directed towards the synthesis of fused nitrogen heterocyclic compound and as an extension of efforts directed towards the development of convenient synthetic approaches for the synthesis one of pyrimidine derivatives called uracil isophenol with an expected broad spectrum of biological activity.

Studies have shown that uracil isophenol exhibit various biological activities.

In biological study was to demonstrate in trial the new compound "uracil isophenol" in different concentration observed the following E.coli exhibit sensitivity to all concentration with differ inhibition zone size ; but the same zone size for (10,15,20) mg/ml the inhibition area was reached for 21 mm .

in spite of difference in concentration.

While Staphylococcus aureus also sensitive and the zone larger than E.coli ,and have the same zone size of E.coli of concentration(3)mg/ml was reached for 15 mm .

While Pseudomonas.aeruginosa also exhibit sensitivity but less than others except for (25) mg/ml it have inhibition zone was reached for size of 25 mm .

Results were compared with control groups were analyzed statistically by results analysis system completely random ANOVA and LSD.