Role of t regulatory cells in chronic HCV infected Egyptian patients and their impact on the response to pegylated interferon therapy
Joint Authors
Naji, Fatin M.
Zuhayri, Muna Z.
al-Ghannam, Majid T.
al-Ahmadi, Walid
Shakir, Zaynab A.
Zada, Suhayr K.
al-Ahwani, Iman G.
al-Rifai, Muhammad
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 45, Issue 2 (31 Aug. 2015), pp.345-356, 12 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
(PEG-IFN) and ribavirin achieves overall response (SVR) rates of ~55 %.
A role of CD4+ CD25 + regulatory T cells (Treg cells) has been proposed as they can suppress HCV-specific T cells in HCV-infected patients.
Patients with chronic HCV legible for PEG-IFN plus ribavirin treatment, were classified according to their response to treatment into two groups (responders and nonresponders, 32 and 27 patients respectively).
Blood and plasma samples were collected at the start of treatment and at 12 and 24 weeks during treatment.
Immunophenotyping by flow cytometry for Treg cells, the FOXP-3 expression using real-time PCR and measurement of IL-10, TGF-β CXCL-9 and CXCL-10 were performed.
Increased expression of Treg cells was detected in patients who didn't respond to treatment before and during treatment.
Also, the levels of IL- 10, TGF-β, CXCL-9 and CXCL-10 revealed significant increase in non-responders all through compared to responders group.
Evaluation of Treg cells, cytokines (IL-10 & TGF-β) and chemokines (CXCL-9 & CXCL-10) before starting the treatment could be a predictor of response to treatment with PEG-IFN plus ribavirin.
The optimum levels which would differentiate between responders and non-responders are needed to be defined before- hand
American Psychological Association (APA)
al-Ahwani, Iman G.& Naji, Fatin M.& Zuhayri, Muna Z.& al-Ghannam, Majid T.& al-Ahmadi, Walid& al-Rifai, Muhammad…[et al.]. 2015. Role of t regulatory cells in chronic HCV infected Egyptian patients and their impact on the response to pegylated interferon therapy. Journal of the Egyptian Society of Parasitology،Vol. 45, no. 2, pp.345-356.
https://search.emarefa.net/detail/BIM-596995
Modern Language Association (MLA)
al-Ahwani, Iman G.…[et al.]. Role of t regulatory cells in chronic HCV infected Egyptian patients and their impact on the response to pegylated interferon therapy. Journal of the Egyptian Society of Parasitology Vol. 45, no. 2 (Aug. 2015), pp.345-356.
https://search.emarefa.net/detail/BIM-596995
American Medical Association (AMA)
al-Ahwani, Iman G.& Naji, Fatin M.& Zuhayri, Muna Z.& al-Ghannam, Majid T.& al-Ahmadi, Walid& al-Rifai, Muhammad…[et al.]. Role of t regulatory cells in chronic HCV infected Egyptian patients and their impact on the response to pegylated interferon therapy. Journal of the Egyptian Society of Parasitology. 2015. Vol. 45, no. 2, pp.345-356.
https://search.emarefa.net/detail/BIM-596995
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 354-355
Record ID
BIM-596995