Role of epithelial mesenchymaltransition in hepatic fibrogenesis
Joint Authors
Zuhayri, Muna Kamil
al-Ahwani, Iman G.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 45, Issue 2 (31 Aug. 2015), pp.357-365, 9 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
extracellular materials.
Two cell types are now well recognized as being involved in liver fibrosis, i.e.
hepatic stellate cells (HSCs) and portal mesenchymal cells.
This process is initiated by the damage of hepatic cells, which leads to activation of hepatic stellate cells that differentiate into myofibroblasts leading to the formation of liver fibrosis.
On the other hand, the epithelialmesenchymal transition and mesenchymal-epithelial transition are crucial for the regulation of cellular plasticity during liver fibrosis.
The EMT is a process in which molecular reprogramming leads epithelial cells to adopt a mesenchymal phenotype.
During EMT, epithelial cells gain mesenchymal features which include changes in the expression of epithelial markers.
The EMT process plays fundamental roles during embryogenesis, tissue fibrosis, and carcinogenesis.
As multiple experimental studies of liver fibrosis have confirmed that established liver fibrosis is reversible upon cessation of the causative agent, modulation of the EMT markers could be promising as potential therapeutic agents.
Better understanding of the molecular cascades of intracellular fibrogenic signaling and genetic factors that controlling the expression of EMT markers would be a powerful strategy for early diagnosis and treatment liver fibrosis at the genetic level.
Activating or silencing of the responsible genes may be an efficient and more specific approach for treating liver fibrosis either through the arrest of EMT or the induction of MET
American Psychological Association (APA)
Zuhayri, Muna Kamil& al-Ahwani, Iman G.. 2015. Role of epithelial mesenchymaltransition in hepatic fibrogenesis. Journal of the Egyptian Society of Parasitology،Vol. 45, no. 2, pp.357-365.
https://search.emarefa.net/detail/BIM-597054
Modern Language Association (MLA)
Zuhayri, Muna Kamil& al-Ahwani, Iman G.. Role of epithelial mesenchymaltransition in hepatic fibrogenesis. Journal of the Egyptian Society of Parasitology Vol. 45, no. 2 (Aug. 2015), pp.357-365.
https://search.emarefa.net/detail/BIM-597054
American Medical Association (AMA)
Zuhayri, Muna Kamil& al-Ahwani, Iman G.. Role of epithelial mesenchymaltransition in hepatic fibrogenesis. Journal of the Egyptian Society of Parasitology. 2015. Vol. 45, no. 2, pp.357-365.
https://search.emarefa.net/detail/BIM-597054
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 365
Record ID
BIM-597054