Effect of tamsulosin drug (Flomax) on fertility in albino male mice
Other Title(s)
تأثير عقار التامسولوسين (الفلوماكس) على الخصوبة في ذكور الفئران البيض
Dissertant
Thesis advisor
Comitee Members
Husayn, Hind
al-Hilfy, Jabar H.
Mahdi, Majida H.
University
University of Baghdad
Faculty
College of Science
Department
Department of Biology
University Country
Iraq
Degree
Master
Degree Date
2012
English Abstract
The present study was conducted to investigate the effect of Tamsulosin hydrochloride on testicular function and fertility in albino male mice (Mus musculus) .
Thirty mature male mice with average body weight of 25-30g and 8-10 weeks of age were randomly divided in to three group (10 mice / group).
The first group was injected intraperitoneally (I.P) with distilled water as a control group and the other groups (second and third) were also injected I.P with two concentrations of Tamsulosin hydrochloride (8 , 16 μg /kg.b.wt) daily for a period of 42 days.
The results showed a significant (p<0.05) decrease in the body weights and rate of testes weights in male mice after the treatment with Tamsulosin hydrochloridefor for two concentrations compared with control group.
The treatment with Tamsulosin hydrochloride also showed a significant (p<0.05) decrease in percentage of sperm motility ,viability and sperm concentrations in the epididymis at dose 16 μg /kg.b.wt compared with the control group but there was no significant (p<0.05) decrease in the percentage of sperm motility and concentrations at dose 8 μg /kg.b.wt ,while there was a significant (p<0.05) decrease in the percentage of viability of sperm at the same dose (8 μg /kg.b.wt ) compared with the control group.
There was also a significant increase (p<0.05) in the percentage of morphologically abnormal sperm for two concentrations (8 , 16 μg /kg.b.wt ) compared with the control group.
Histological examination of testes indicated that the treatment with the drug induced a significant (p<0.05) decrease in seminiferous tubules , primary spermatocytes ,spermatid and decrease in number of the leydig’s cells Summary II clusters, while there was a significant (p<0.05) increase in the interstitial space between tubules comparing with the control group.
The histological examination also revealed an existence of some changes in the testes such as necrosis in the tubule and oedema in the interstitial spaces The treatment with all concentrations also caused a significant (p<0.05) decrease in the testosterone levels in blood serum comparing with the control group .
It was concluded from this investigation that Tamsulosin has a negative effect on testicular function (fertility).
Main Subjects
No. of Pages
91
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction and literature review.
Chapter Two : Materials and methods.
Chapter Three : Results and discussion.
Conclusions and recommendations.
References.
American Psychological Association (APA)
Ali, Dina Khudayr Husayn. (2012). Effect of tamsulosin drug (Flomax) on fertility in albino male mice. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-597613
Modern Language Association (MLA)
Ali, Dina Khudayr Husayn. Effect of tamsulosin drug (Flomax) on fertility in albino male mice. (Master's theses Theses and Dissertations Master). University of Baghdad. (2012).
https://search.emarefa.net/detail/BIM-597613
American Medical Association (AMA)
Ali, Dina Khudayr Husayn. (2012). Effect of tamsulosin drug (Flomax) on fertility in albino male mice. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-597613
Language
English
Data Type
Arab Theses
Record ID
BIM-597613
