Radiation pollution in cancer and other diseases using some immunological and clinical parameters

Other Title(s)

التلوث الإشعاعي في مرضي السرطانات و أمراض أخرى باستخدام معلمات مناعية و سريرية

Dissertant

al-Hamdani, Wiam Sad

Thesis advisor

Salih, Duha Sad
Shanshal, Muthanna Abd al-Jabbar

Comitee Members

Muhammad, Lamia Y.
Shafiq, Shafiq S.
Ali, Muhammad N.
Adhiah, Ali Husayn
Isa, Rajwa Hasan

University

University of Baghdad

Faculty

College of Science

Department

Department of Biology

University Country

Iraq

Degree

Ph.D.

Degree Date

2011

English Abstract

A total of 88 individuals, 45 patients and 43 healthy persons, that blood samples were taken during the period (October 2009 to September 2010) from the outpatients of the Institute and Hospital of Radiotherapy and Nuclear Medicine and Al- Kadhymia Teaching Hospital in Baghdad.

Patients involved the cases that suffering from cancers, congenital malformations, spontaneous abortion and molar pregnancy, while healthy persons were taken from Iraqi community healthy peoples with ages similar to those of patients.

The present study concerned with the effects of internal exposure to Uranium (U) radiation on human immune system using some viable parameters, which was done for the first time in Iraq.

The concentrations of Uranium were estimated in blood samples using the technique of CR-39 Polymer; one of SSNTDs methods (Solid State Nuclear Track Detectors).

This estimation was carried out to determine the elevated Uranium levels in blood samples.

Parameters related to radiation pollution exposure; which were estimated in blood samples involved: Total W.B.C.s counts, Differential W.B.C.s counts, Haemoglobin concentrations, NBT Reduction Tests for Neutrophils phagocytic activity detection, and ELISA Tests for IFN-γ and IL-2 levels determination.

The present study took into consideration the demographic distribution of peoples in relation to radiation exposure on several Iraqi governorates and investigated the most affected peoples in relation to their residency.

Also there were statistical data that collected from Al-Karhk and Al-Rasafa Health Bureaus which involved all Baghdad hospitals.

This information was about the incidence of cancers and malformations in newborn and the most frequent type of these cases during 2010.

The results indicated for the followings: V 1.

Contaminated peoples with Uranium; or Depleted Uranium; were 48 persons representing 54.5% from the total 88 individuals that were involved in this study.

2.

There were five locations (from a total 26 places all over Iraq that blood samples were collected from) which had predominant ratios of contaminated residents with U, these places were in Baghdad (Al-Taji, Abu-Graib, Al-Hurriyah, New Baghdad and Al-Sader town) respectively, and constituted 44.7% from the total contaminated persons.

According to other Governorates; the governorates (Al- Kut, Al-Anbar, and Al-Basra) have had the highest cases number respectively.

3.

There was a statistical relation between this study patients cases incidence and U contamination which might be a predisposing factor that responsible for developing their cases since U were able to cause immunosuppresion by affecting on immune cells by number or function comparing with the non contaminated individuals.

4.

Internal contamination with U; chronic radiation exposure; had different effects on the parameters that were used in this study.

It was influenced by the dose of exposure and personal susceptibility, thus it caused decrease in some Eosinophils and Lymphocytes relative numbers, Hb% concentrations, NBT positive percentages and most of the cytokine IFN-γ levels, while there were some elevation in Basophils percentages recorded.

5.

The cytokine IL-2 levels did not affected by chronic exposure to radiation by U contamination.

But it was affected by acute exposure to radiation since its levels raised significantly in radiation occupationals.

6.

Statistical data results indicated that there was an increase in Breast cancer percentages of incidence comparing with other types, also there were variations in malformation percentages incidence in Baghdad Hospitals among new births; but generally; there was a significant increase in cases related to radiation pollution (Cephalic & Digestive system anomalies).

Main Subjects

Medicine

Topics

• Cancer
• Radiotherapy
• Health aspects

No. of Pages

123

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-598692