Effect of vitamin d supplementation on insulin resistance in vitamin d-deficient obese Saudi females ; randomized controlled trial

Abstract EN

This study evaluates the ejects of vitamin D supplementation on insulin resistance in vitamin ه deficient oطese Saudi females.

Thirty vitamin D deficient oطese female students were recruited from University of Dammam, Saudi Arabia and divided into a vitamin D group and a placebo group.

Homeostasis model assessment of insulin resistance was compared between the groups and within the groups by two sample ttest and paired t test, respectively.

Aftertreatment with 50,000 ١٧ of vitamin D weekly for 8 weeks, the mean plasma levels of Zh^raxy-vitamin D was significantly increased from 2.9 to 31.3 ng/ ml in the vitamin D group.

^e results in the vitamin D supplemented group at baseline and at the end, for fasting plasma glucose were 97.90 ± 2.13 and 101.01 ± 1.67 mg/dl (P = 0.21), for insulin, 5.14 ± 3.22 and 4.68 ± 3.24 niu/ml (P = 0.15) and for Homeotfasis model assessment of insulin resistance, 1.28 ± 0.81 and 1.23 ± 0.87 (P = 0.62), respectively.

This data showed insignificant changes in insulin resistance after treatment with vitamin D, suggesting that vitamin D supplementation may not have any effect on insulin resistance in vitamin D deficient obese females