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The effect of insulin induced hypoglycemia on ketoconazole hepatototxicity in rabbit
Other Title(s)
تأثير نقص السكر في الدم الناجم عن الأنسولين على سمية الكبد الناتجة عن الكيتوكونازول في الأرانب
Joint Authors
Anaed, Riyad H. Zayir
Ali, Nabil A. J.
Source
The Medical Journal of Basrah University
Issue
Vol. 33, Issue 1 (30 Jun. 2015), pp.17-23, 7 p.
Publisher
University of Basrah College of Medicine
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Hypoglycemia is one of the most common side effect of insulin treatment, it affect liver and can potentiate ketoconazole toxicity.
Objectives: To measure effect of ketoconazole on liver enzymes, hypoglycemic oxidative stress and to evaluate if N-acetylcysteine, can modulate this effect.
Methods: Thirty five male rabbits were randomly divided into five groups: Group 1: (control group), Group 2:( ketoconazole), Group 3: (insulin), Group 4: ( ketoconazole+ insulin), Groups 5: (ketoconazole + insulin + N-Acetyl cysteine).
Animals were sacrificed at day 3.
Blood collected for measurement of liver enzymes, and total bilirubin.
Malondialdehyde and glutathione were measured in serum and liver.
Results: Ketoconazole increased serum and liver malondialdehyde, 0.594 ± 0.17 and 4614.49 ± 1288.00 nmol/gm.
Increased aspartate aminotransferase 38.19 ± 17.29 and alkaline phosphatase 29.29 ± 10.2 U/L.
Insulin increased serum malondialdehyde 0.522 ± 0.19, alkaline phosphatase 15.77 ± 6.12 U/L and bilirubin 0.56 ± 0.26 mg/dl.
Ketoconazole + insulin, increased serum malondialdehyde 0.850 ± 0.16 μmol/l and bilirubin 0.77 ± 0.55 mg/dl.
Ketoconazole + insulin increased serum malondialdehyde 0.850 ± 0.16 μmol/l, aspartate amino transferase 54.35 ± 18.34 U/L, alanine amino transferase, 34.74 ± 11.08 U/L, alkaline pohospahtase 30.81 ± 12.4 U/L and bilirubin 2.51 ± 1.55 mg/dl.
N-acetylcysteine reduced aspartate aminotransferase 28.12 ± 22.21 U/L, alkaline phosphatase 11.81 ± 3.03 IU/L) and bilirubin 0.39 ± 0.18 mg/dl Conclusion: Hypoglycemia caused hepatotoxicity and oxidative stress and potentiates the toxicity of ketoconazole.
N-acetylcysteine partly reverse this hepatotoxicity.
American Psychological Association (APA)
Anaed, Riyad H. Zayir& Ali, Nabil A. J.. 2015. The effect of insulin induced hypoglycemia on ketoconazole hepatototxicity in rabbit. The Medical Journal of Basrah University،Vol. 33, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-600089
Modern Language Association (MLA)
Anaed, Riyad H. Zayir& Ali, Nabil A. J.. The effect of insulin induced hypoglycemia on ketoconazole hepatototxicity in rabbit. The Medical Journal of Basrah University Vol. 33, no. 1 (Jun. 2015), pp.17-23.
https://search.emarefa.net/detail/BIM-600089
American Medical Association (AMA)
Anaed, Riyad H. Zayir& Ali, Nabil A. J.. The effect of insulin induced hypoglycemia on ketoconazole hepatototxicity in rabbit. The Medical Journal of Basrah University. 2015. Vol. 33, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-600089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 22-23
Record ID
BIM-600089