The use of alphacalcidol intravenously in hemodialysis patients : experience from Bahrain
Joint Authors
al-Arid, Samir
Seshadri, Rajagopalan
Nagalla, Sivamohandas
al-Khayyat, Muhammad Hasan
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 14, Issue 2 (28 Feb. 2003), pp.158-164, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2003-02-28
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
While the effects of vitamin D, one-alphahydroxychole calciferol (alphacalcidol) administered intravenously on the serum levels of parathormone (PTH) and calcium in dialysis patients have been well studied in the past few years, no detailed studies were conducted in patients from this part of the world.
We studied nine patients (four men and five women) who received this drug for 12 weeks.
The mean age of the patients was 54.4 ± 19.8 (range: 23-81) years and the duration on dialysis was 40.1 ± 15.6 (range: 18-62) months.
The patients were selected on the basis of baseline serum intact PTH values of more than twice the upper limit of normal ; all of the patients were on oral alphacalcidol, which was stopped before the study.
Alphacalcidol was administered during the last fifteen minutes of each dialysis session, three times per week.
The dose of the drug was up regulated weekly to a maximum of 6µg per session according to the degree of suppression of PTH and / or the development of hyperkalemia.
The results showed a significant decrease of the mean serum PTH from baseline of 77.58 ± 49.13 to 41.87 ± 48.87 pmol / L (p<0.02).
Serum phosphate 2.01 ± 0.27 and calcium 2.38 ± 0.25 did not change significantly from baseline.
None of the patients developed local or systemic adverse reaction to the injection ; only one patient developed hyperkalemia requiring short interruption of the vitamin D with later resumption at a lower dose.
In conclusion, alphacalcidol administered intravenously is effective and safe in hemodialysis patients.
American Psychological Association (APA)
al-Arid, Samir& Seshadri, Rajagopalan& Nagalla, Sivamohandas& al-Khayyat, Muhammad Hasan. 2003. The use of alphacalcidol intravenously in hemodialysis patients : experience from Bahrain. Saudi Journal of Kidney Diseases and Transplantation،Vol. 14, no. 2, pp.158-164.
https://search.emarefa.net/detail/BIM-60040
Modern Language Association (MLA)
al-Arid, Samir…[et al.]. The use of alphacalcidol intravenously in hemodialysis patients : experience from Bahrain. Saudi Journal of Kidney Diseases and Transplantation Vol. 14, no. 2 (Dec. 2003), pp.158-164.
https://search.emarefa.net/detail/BIM-60040
American Medical Association (AMA)
al-Arid, Samir& Seshadri, Rajagopalan& Nagalla, Sivamohandas& al-Khayyat, Muhammad Hasan. The use of alphacalcidol intravenously in hemodialysis patients : experience from Bahrain. Saudi Journal of Kidney Diseases and Transplantation. 2003. Vol. 14, no. 2, pp.158-164.
https://search.emarefa.net/detail/BIM-60040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 163-164
Record ID
BIM-60040