Atomic absorption, HPLC and spectrophotometric determination of some antibiotics in pharmaceutical preparations via complexes formation with Au (III) and Hg (II) ions
Other Title(s)
تعيين بعض المضادات الحيوية بطرائق الامتصاص الذري و كروماتوغرافيا السائل ذات الأداء العالي و المطيافية الجزيئية عن طريق تكوين معقدات مع أيونات الذهب (III) و الزئبق (II)
Dissertant
Thesis advisor
Jasim, Hadi Hasan
Abd al-Ghani, Ahlam Jamil
Comitee Members
al-Rufai, Ilham M.
Dikran, Sarmd B.
Jalhum, Muayyad G.
Ilyas, Mahasin Faysal Ahmad
University
University of Baghdad
Faculty
College of Science
Department
Chemistry Department
University Country
Iraq
Degree
Ph.D.
Degree Date
2011
English Abstract
The experimental conditions for the chelate formation for gold complexes :- Concentration of Au ion was (10) ppm and (15)ppm for metronidazole : pH(2-3): aqueous to organic phase ratio (5:1) : reaction time (10 ) minutes : extraction time (2) minutes , one minutes for tetracycline and metronidazole : one - extraction process (96.817% , 95.714%, 93.626% ,95.241%, 96.652%)for all drugs respectively .
Benzyl alcohol proved to be the best organic solvent for extraction of the β- lactames complexes , ethyl acetate for Tetracycline complexes , and chloroform for Metronidazole without interference .
The analytical figures of merits obtained on applying the developed procedure for Ampicillin , Amoxicillin , Cephalexin , Tetracycline and Metronidazole determination resp.
was : - Linear dynamic range (5-60ppm) for Amp., Amox.
, and Cephalexin , (5-70) for tetracycline , and (5-55ppm)for metronidazole .
LOD (0.236, 0.305, 0.202, 0.740, 0.507) μg.ml-1.
Erel% (1.050%, 1.025%, 1.077%, 0.783%, 1.072%).
Recovery% (101.050%, 101.024%, 101.06%, 100.78%, 101.07%).
The structures of the gold-Drug complex for the five drugs were found to be 1:1 (M:L) ,the stability constants of the five complexes are (8.4950×105 , 1.1611×105 , 1.1630×104 , 2.5187×104 ,1.6478×104 )M-1 resp.
Main Subjects
Topics
No. of Pages
152
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental.
Chapter Three : Results and discussion.
References.
American Psychological Association (APA)
al-Kazimi, Abbas Shabib Hasan. (2011). Atomic absorption, HPLC and spectrophotometric determination of some antibiotics in pharmaceutical preparations via complexes formation with Au (III) and Hg (II) ions. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600497
Modern Language Association (MLA)
al-Kazimi, Abbas Shabib Hasan. Atomic absorption, HPLC and spectrophotometric determination of some antibiotics in pharmaceutical preparations via complexes formation with Au (III) and Hg (II) ions. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad. (2011).
https://search.emarefa.net/detail/BIM-600497
American Medical Association (AMA)
al-Kazimi, Abbas Shabib Hasan. (2011). Atomic absorption, HPLC and spectrophotometric determination of some antibiotics in pharmaceutical preparations via complexes formation with Au (III) and Hg (II) ions. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600497
Language
English
Data Type
Arab Theses
Record ID
BIM-600497
