Proliferative and apoptotic indices in squamous epithelial lesions of the cervix
Joint Authors
David, Saritha
Rao, Saraswati G.
Mysorekar, Vijaya V.
Source
Issue
Vol. 30, Issue 4 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
King Hamad University Hospital
Publication Date
2008-12-31
Country of Publication
Bahrain
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Cell proliferation is an important feature of dysplasia and carcinoma.
Cell death (apoptosis) is another phenomenon which is responsible for the control of cell number in normal and neoplastic tissue.
Simple indices can be used to measure cell proliferation and apoptosis.
Objective : To compare the proliferative and apoptotic indices in various cervical squamous epithelial lesions, and to determine their prognostic value.
Method: Two hundred lesions were evaluated for their morphology, apoptotic index (AI), mitotic index (MI), and argyrophilic nucleolar organiser region (AgNOR) counts.
Result : Mean AI, MI and AgNOR counts significantly increased from benign lesions, to cervical intraepithelial neoplasia (CIN), to invasive carcinoma.
Conclusion : AI, MI and AgNOR counts are useful cell kinetic analysis because they reflect the frequency of two important events, namely mitosis and cell death.
These counts can be useful as prognostic markers and aid patient management decisions.
American Psychological Association (APA)
Mysorekar, Vijaya V.& David, Saritha& Rao, Saraswati G.. 2008. Proliferative and apoptotic indices in squamous epithelial lesions of the cervix. Bahrain Medical Bulletin،Vol. 30, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-601934
Modern Language Association (MLA)
Mysorekar, Vijaya V.…[et al.]. Proliferative and apoptotic indices in squamous epithelial lesions of the cervix. Bahrain Medical Bulletin Vol. 30, no. 4 (Dec. 2008), pp.1-6.
https://search.emarefa.net/detail/BIM-601934
American Medical Association (AMA)
Mysorekar, Vijaya V.& David, Saritha& Rao, Saraswati G.. Proliferative and apoptotic indices in squamous epithelial lesions of the cervix. Bahrain Medical Bulletin. 2008. Vol. 30, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-601934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-601934