![](/images/graphics-bg.png)
A possible role for Chlamydia pneumoniae in vaso-occlusive crisis in sickle cell disease
Joint Authors
al-Bahrani, Ali
al-Yusuf, Habib
Mustafa, Basim
Majid, Maytham
Bakhit, Muizz
Source
Issue
Vol. 32, Issue 3 (30 Sep. 2010), pp.1-7, 7 p.
Publisher
King Hamad University Hospital
Publication Date
2010-09-30
Country of Publication
Bahrain
No. of Pages
7
Main Subjects
Abstract EN
Background : Vaso-occlusive crisis (VOC) is the most common complication in sickle cell disease (SCD); it causes a wide spectrum of end-organ damage, a process found to be mediated by inflammatory responses.
Through activating endothelial and immune cells, Chlamydia pneumoniae (Cp) infection was postulated to be a factor in the morbidity of acute chest syndrome in sickle cell patients (SCP).
Objective : To provide serological evidence of a possible role of Cp in VOC in SCD by investigating the occurrence of Cp IgG and IgA antibodies in SCD patients compared to control subjects.
Design : Open Controlled Trial.
Setting : Bahrain Defense Force Hospital and Princess Al-Jawhara Center for Molecular Medicine, Arabian Gulf University Bahrain.
Method : Venous blood samples were collected from one hundred and twelve patients who had acute phase of VOC and from one hundred and twelve controls.
Anti-Cp IgG and IgA antibodies were detected by using species specific Cp IgG and IgA enzyme immunoassay (EIA) kits, in both patients and controls sera.
Parametric comparisons were performed using t-test.
Result : The results showed a significant difference in Cp IgG and IgA antibodies prevalence between patients and controls (P<0.0001).
Dual Cp IgG and IgA seropositive were higher in patients than controls.
Conclusion : The study provided serological evidence of a possible role of Cp infection in VOC in the SCD.
American Psychological Association (APA)
al-Yusuf, Habib& Mustafa, Basim& Majid, Maytham& Bakhit, Muizz& al-Bahrani, Ali. 2010. A possible role for Chlamydia pneumoniae in vaso-occlusive crisis in sickle cell disease. Bahrain Medical Bulletin،Vol. 32, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-602245
Modern Language Association (MLA)
al-Bahrani, Ali…[et al.]. A possible role for Chlamydia pneumoniae in vaso-occlusive crisis in sickle cell disease. Bahrain Medical Bulletin Vol. 32, no. 3 (Sep. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-602245
American Medical Association (AMA)
al-Yusuf, Habib& Mustafa, Basim& Majid, Maytham& Bakhit, Muizz& al-Bahrani, Ali. A possible role for Chlamydia pneumoniae in vaso-occlusive crisis in sickle cell disease. Bahrain Medical Bulletin. 2010. Vol. 32, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-602245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-602245