To evaluate the effect of Wobe Mugos hydrolytic enzyme therapy on inflammation induced by external radiotherapy in patients of head and neck cancers.

Abstract EN

Objective: Our aim of this study was to evaluate the effect of enzymes in reducing inflammation produced by external radiotherapy.

Methods: Fifty consecutive patients of oral and oropharyngeal cancers under going external radiotherapy as the modality of treatment were alternated in two groups.

A group of 25 patients were treated with external radiotherapy and 3 tablets of Wobeenzyme three times a day.

Other group of 25 patients were treated with conventional radiotherapy alone.

Results: In the control group of patients who received radiotherapy only, we found 8% of patients had grade I, 68% had grade II, 24% had grade III mucosal reaction respectively.

In comparison to the enzyme group the mucosal reaction found that 76% had grade I, 14% had grade II and only 10% had grade III respectively.

The data had significant P value.

Nutritional status and Quality of life also improved in enzyme group.

Conclusion: In our study we found hydrolytic enzymes offers several advantages over routinely used anti inflammatory agents.

They include better vascularisation of mucosa, improved microcirculation, elimination of undesirable products of inflammation.

Wobe-enzyme is innovative, improved advancement designed to focus on acute and sub acute inflammation of various origins.

They are prerequisite of good patient compliance and economical therapy.