Obesity and serum uric acid

Abstract EN

Objective: To study the serum level of uric acid among obese individuals and to identify the dominant risk factors for elevated serum uric acid.

Setting: International Academy Rehabilitation Sport, Irbid – Jordan.

Design: Cross-Sectional study.

Method: Three hundred healthy adult males aged 30-50 years were included in the study.

The sample was divided into approximately equal three groups based on obesity categories.

Plasma uric acid, total cholesterol, triglycerides, low density lipoprotein- cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), fasting blood glucose (FBG), blood pressure, height, weight and waist circumference were measured and a pre-tested.

Structured questionnaire was administered by trained-interviewer.

Result: A graded increase of serum uric acid rates was observed with increased body weight and waist circumference.

The serum uric acid among overweight and obese subjects compared with non-obese subjects were 5.6 and 10.8 times respectively.

Logistic regression analysis showed that the amount of body fat and distribution were the major risk factors for elevated serum uric acid; other factors such as obesity during adolescence, calories from dietary protein ≥16.5% and creatinine play a minor role.

Conclusion: Elevated serum uric acid is more prevalent in obese individuals.

Obesity is the dominant risk factor for elevated serum uric acid.