Protective effect of berberine chloride on plasmodium chabaudi-induced hepatic tissue injury in mice
Joint Authors
Dkhil, Muhammad A.
al-Shamrani, Ahmad
al-Azzuni, Ahmad S.
Lubbad, Mahmud Y.
al-Shaybi, Isam M.
Tayyib, Nuri T.
al-Qurashi, Salih
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 5 (30 Sep. 2015), pp.551-555, 5 p.
Publisher
Publication Date
2015-09-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The present study aimed to investigate the protective role of berberine (BER) against Plasmodium chabaudi-induced infection in mice.
Animals were divided into three groups.
Group I served as a vehicle control.
Group II and group III were infected with 1000 P.
chabaudi infected erythrocytes.
Group III was gavaged with 100 ll of 10 mg/kg berberine chloride for 10 days.
All mice were sacrificed at day 10 post-infection.
The percentage of parasitemia was significantly reduced more than 30%, after treatment of mice with BER.
Infection caused marked hepatic injuries as indicated by histopathological alterations as evidenced by the presence of hepatic lobular inflammatory cellular infiltrations, dilated sinusoids, vacuolated hepatocytes, increased number of Kupffer cells and the malaria pigment, hemozoin.
These changes in livers led to the increased histological score.
Also, infection induced a significant increase in liver alanine aminotransferase and aspartate aminotransferase and a significant increase in the total leucocytic count.
Moreover, mice became anemic as proved by the significant decrease in erythrocyte number and haemoglobin content.
BER showed a significant protective potential by improving the above mentioned parameters.
Based on these results, it is concluded that berberine could offer protection against hepatic tissue damage.
American Psychological Association (APA)
Dkhil, Muhammad A.& al-Qurashi, Salih& al-Shamrani, Ahmad& al-Azzuni, Ahmad S.& Lubbad, Mahmud Y.& al-Shaybi, Isam M.…[et al.]. 2015. Protective effect of berberine chloride on plasmodium chabaudi-induced hepatic tissue injury in mice. Saudi Journal of Biological Sciences،Vol. 22, no. 5, pp.551-555.
https://search.emarefa.net/detail/BIM-604268
Modern Language Association (MLA)
Dkhil, Muhammad A.…[et al.]. Protective effect of berberine chloride on plasmodium chabaudi-induced hepatic tissue injury in mice. Saudi Journal of Biological Sciences Vol. 22, no. 5 (Sep. 2015), pp.551-555.
https://search.emarefa.net/detail/BIM-604268
American Medical Association (AMA)
Dkhil, Muhammad A.& al-Qurashi, Salih& al-Shamrani, Ahmad& al-Azzuni, Ahmad S.& Lubbad, Mahmud Y.& al-Shaybi, Isam M.…[et al.]. Protective effect of berberine chloride on plasmodium chabaudi-induced hepatic tissue injury in mice. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 5, pp.551-555.
https://search.emarefa.net/detail/BIM-604268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 555
Record ID
BIM-604268