Prevalence of oral candida infections in diabetic patients
Joint Authors
Abu al-Tin, Khalid H.
Salah, Sulayman A.
Hamad, Mawieh A.
Source
Issue
Vol. 28, Issue 1 (31 Mar. 2006), pp.1-8, 8 p.
Publisher
King Hamad University Hospital
Publication Date
2006-03-31
Country of Publication
Bahrain
No. of Pages
8
Main Subjects
Abstract EN
Objective: The purpose of this study was to determine the prevalence, species distribution and antifungal susceptibility profile among oral cavity isolates of Candida species from diabetic and non-diabetic subjects.
The contribution of smoking and dental status to the prevalence and distribution of Candida species was also evaluated.
Design: Retrospective study of oral cadidiasis in diabetic patients between January and October 2003 was undertaken.
Setting: Three private clinics in Amman, Jordan and Department of Biological Sciences at Hashemite University.
Method: A total of 262 individuals were enrolled in the study, 132 were diabetics and 130 healthy controls.
None of the non-diabetic controls had any clinical evidence of oral candidiasis, 8.3% of diabetics had clinical evidence of oral candidiasis, of which, 36% were overnight denture wearers and tobacco smokers.
An imprint culture method was used to determine the frequency of isolation and density of Candida species at up to nine intra-oral sites.
Yeast-like colonies were identified by classical methods and CHROMagar Candida medium.
Broth macrodilution technique was used to determine the antifungal susceptibility pattern of Candida isolates.
Results: Positive yeast was detected in 58.3% of diabetics compared with 30% in healthy controls (P<0.001).
C.
albicans was the most prevalent species in both diabetics (81.8%) and controls (76.9%) followed by C.
tropicalis, C.
parapsilosis and C.
glabrata.
C.
kefyr and C.
krusei were isolated only from diabetics at a combined rate of 1.3%.
Candida was detected more frequently in diabetic denture wearers than in control counterparts in all anatomic sampled sites (P<0.05).
The frequency of Candida isolation was significantly higher in smokers than in the non-smokers in both diabetics and controls (P<0.001).
All C.
albicans recovered from diabetics and controls were susceptible to amphotericin B, ketoconazole, itraconazole and fluconazole.
Non-albicans Candida isolates were shown to have higher azole MIC values than C.
albicans isolates.
Conclusions: Our findings show that smoking and continuously worn dentures, promote oral candidal colonization in diabetics.
American Psychological Association (APA)
Abu al-Tin, Khalid H.& Hamad, Mawieh A.& Salah, Sulayman A.. 2006. Prevalence of oral candida infections in diabetic patients. Bahrain Medical Bulletin،Vol. 28, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-604437
Modern Language Association (MLA)
Abu al-Tin, Khalid H.…[et al.]. Prevalence of oral candida infections in diabetic patients. Bahrain Medical Bulletin Vol. 28, no. 1 (Mar. 2006), pp.1-8.
https://search.emarefa.net/detail/BIM-604437
American Medical Association (AMA)
Abu al-Tin, Khalid H.& Hamad, Mawieh A.& Salah, Sulayman A.. Prevalence of oral candida infections in diabetic patients. Bahrain Medical Bulletin. 2006. Vol. 28, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-604437
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 7-8
Record ID
BIM-604437