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A comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity
Joint Authors
Ergin, Ahmet B.
al-Sayyid, Murad
Erdur, Bulent
Kortunay, Selim
Yuksel, Aykut
Yilmaz, Atakan
Ozen, Mert
Uyanik, Aykut
Tomruk, Onder
Source
Basrah Journal of Veterinary Research
Issue
Vol. 14, Issue 1 (30 Jun. 2015), pp.1-5, 5 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: The treatment of cocaine toxicity is an important subject for emergency physicians.
We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicity in mice.
Objectives: The aim of this study was to evaluate the effects of dexmedetomidine, moxonidine and alpha-methyldopa in a mouse model of acute cocaine toxicity.
Materials and Methods: We performed an experiment consisting of four groups (n = 25 each).
The first group received normal saline solution, the second group received 40 μg/kg of dexmedetomidine, the third group received 0.1 mg/kg of moxonidine and the fourth group received 200 mg/kg of alpha-methyldopa, all of which were intraperitoneally administered 10 minutes before cocaine hydrochloride (105 mg/kg).
All animals were observed for seizures (popcorn jumping, tonic-clonic activity, or a loss of the righting reflex) and lethality over the 30 minutes following cocaine treatment.
Results: The ratio of animals with convulsions was lower in all treated groups when compared to the control (P < 0.001).
Furthermore, 68% (n = 17) of animals in the dexmedetomidine group, 84% (n = 21) of the alpha-methyldopa group, 92% (n = 23) of the moxonidine group and 100% (n = 25) of the control group showed evidence of seizure activity (P = 0.009).
Cocaine-induced lethality was observed in 12% (n = 3) of the dexmedetomidine group, 48% (n = 12) of the alpha-methyldopa group, 52% (n = 13) of the moxonidine group, and 72% (n = 18) of the control group (P < 0.001).
All treatments prolonged the time to seizure, which was longest in the dexmedetomidine group (P > 0.05).
In addition, the time to lethality was also longer in the same group (P < 0.001).
Conclusions: The present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures.
Premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity.
In addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality.
American Psychological Association (APA)
al-Sayyid, Murad& Erdur, Bulent& Kortunay, Selim& Yuksel, Aykut& Yilmaz, Atakan& Ozen, Mert…[et al.]. 2015. A comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity. Basrah Journal of Veterinary Research،Vol. 14, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-605354
Modern Language Association (MLA)
al-Sayyid, Murad…[et al.]. A comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity. Basrah Journal of Veterinary Research Vol. 14, no. 1 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-605354
American Medical Association (AMA)
al-Sayyid, Murad& Erdur, Bulent& Kortunay, Selim& Yuksel, Aykut& Yilmaz, Atakan& Ozen, Mert…[et al.]. A comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity. Basrah Journal of Veterinary Research. 2015. Vol. 14, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-605354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-605354