Effect of bisphenol a on thyroid, liver and testicular functions in adult male rats

Abstract EN

This study was carried out in Veterinary Medicine College / University of Basrah to investigate the effect of Bisphenol A on thyroid, liver and testicular functions.

A total of 24 adult male rats were randomly divided into four equal groups, six animals in each group.

Animal of group (1) served as control and received a daily oral administration of corn oil throughout the experimental protocol.

Animals of group 2, 3 and 4 were administered orally 50,100 and 200 mg/kg body weight of BPA respectively dissolved in corn oil, the experiment extended for 30 days.

The results of the present study showed a significant decrease in serum thyroxin (T4) concentration and a significant increase in serum aspartate aminotransferase ( AST) and alanine aminotransferase ( ALT) concentration in bisphenol A treated groups.

A significant decrease in serum testosterone and LH concentrations in all BPA-treated groups compared with control.

On other hand non significant decrease in serum concentrations of FSH were observed in BPA-treated groups compared with control.

A significant decrease in epididymal sperm count and sperms motility in all BPA treated groups.

However no significant differences were noted in sperms viability between all BPA treatment groups and control.

Histopathological changes were found in thyroid glands of male rats with different doses of BPA, also central vein dilation, enlarged nuclei, vacuolation of hepatocytes were observed in the liver of BPA treated groups and different degrees of histological changes include depression of spermatogenesis, decrease of leydig cells in dose dependent manner were found in testicular tissues of BPA treated groups.