Diamond Blackfan Anaemia (DBA)‎ in association with polydactyly : response to antilymphocyte globulin (ALG)‎

Abstract EN

An 8-month old Saudi Arabian boy presented with Diamond Blackfan Anaemia (DBA) and polydac-tyly.

He required support with monthly red blood cell (RBC) transfusions.

Although his bone marrow showed erythroblastopenia with giant pro-erythroblasts, ex-amination of a later serum sample showed no evidence of B19 parvovirus DNA, and significant amounts of IgM and Igg anti-B19 antibodies.

He showed no clini-cal improvement on a 3-month course of prednisone alone, subsequently followed by concommittant oxymethalone for 5 months.

However, a و day course of daily infusion of ant؛ lymphocyte globin (ALG) was followed by a significant improvement in haemoglobin.

Although he briefly suffered a relapse about 9 months later, he recovered spontaneously and has been in complete remission since.

We conclude that some patients with DBA may benefit from treatment with ALG.