High expression of p53 protein in toxoplasmosis among women with spontaneous miscarriage in Basrah

Abstract EN

Recurrent abortion is a worldwide problem, with undefined causes.

Apoptosis could play a major role in the process.

The Objective of the work to detect the expression of p53 protein at the materno-fetal interface in patients with recurrent pregnancy loss (RPL).

Immunohistochemistry analysis of P53 protein using paraffin embedded sections of curate samples obtained from 40 women divided into three groups : 16 women with recurrent abortion as postive with toxoplasmosis,10 women with recurrent abortion negative of toxoplasmosis and14 women with no histry of abortion as control group .

The mean value of the expression of P53 protein was (40.87± 7.54),which is significantly higher than that of the second group(28.2± 4.89),and the third group (13.07± 4.49).

The high expression of p53 protein in women with RPL may have a role in accelerating placental apoptosis leading to failure of pregnancy.