The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease
Other Title(s)
دور وسائط الالتهاب في الآلية المرضية لداء الزهايمر
Joint Authors
Navabi, Shadi Sadat
Seyedzadeh, Mir Hadi
Yazdani, Rida
al-Shukaili, Ahmad
Mirshafiey, Abbas
Uzayzi, Ghulam Rida
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 15, Issue 3 (31 Aug. 2015), pp.305-316, 12 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2015-08-31
Country of Publication
Oman
No. of Pages
12
Main Subjects
Topics
Abstract EN
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally.
AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation.
Inflammation of the brain is a key pathological hallmark of AD.
Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators.
In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain.
This review provides an overview of the functions and activities of inflammatory mediators in AD.
An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.
American Psychological Association (APA)
Uzayzi, Ghulam Rida& Navabi, Shadi Sadat& al-Shukaili, Ahmad& Seyedzadeh, Mir Hadi& Yazdani, Rida& Mirshafiey, Abbas. 2015. The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease. Sultan Qaboos University Medical Journal،Vol. 15, no. 3, pp.305-316.
https://search.emarefa.net/detail/BIM-606210
Modern Language Association (MLA)
al-Shukaili, Ahmad…[et al.]. The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease. Sultan Qaboos University Medical Journal Vol. 15, no. 3 (Aug. 2015), pp.305-316.
https://search.emarefa.net/detail/BIM-606210
American Medical Association (AMA)
Uzayzi, Ghulam Rida& Navabi, Shadi Sadat& al-Shukaili, Ahmad& Seyedzadeh, Mir Hadi& Yazdani, Rida& Mirshafiey, Abbas. The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease. Sultan Qaboos University Medical Journal. 2015. Vol. 15, no. 3, pp.305-316.
https://search.emarefa.net/detail/BIM-606210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 313-316
Record ID
BIM-606210