Evaluation of brain natriuretic peptide levels in sera of Iraqi patients with hyperthyroidism and hypothyroidism

Abstract EN

The thyroid gland is endocrine gland that is normally located in the lower front of the neck .Cardiovascular changes that accompany thyroid disorders could be stimulus for the release of BNP from heart ventricles.

Different factors, including stress environment conditions, have important role in pathogenesis of thyroid disorders and could possibly affect this response.

Brain natriuretic peptide (BNP) is secreted from the ventricular myocardium in response to volume expansion and pressure overload.

Serum BNP levels are also affected by thyroid function status, which was mostly related to a direct stimulatory effect of thyroid hormones on the secretion of BNP.

Serum levels of brain natriuretic peptide showed a highly significant increase in hyperthyroidism group compared with control group (p<0.01) and highly significant decrease in hypothyroidism group compared with control group.

The results revealed a significant positive correlation between and T3,T4 and BNP level in patients with hyperthyroidism while there was no significant correlation between the corresponding thyroid hormones and BNP level in patients with hyporthyroidism.