Erythropoietin level in acute leukemia

Abstract EN

Background : Acute leukemia is a proliferation of immature bone marrow-derived cells (blasts) that may also involve peripheral blood or solid organs.

Erythropoietin, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production also has other range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis,and inducing proliferation of smooth muscle fibers.

Objective : to evaluate serum level of erythropoietin in patients with acute leukemia.

Research design and methods : In this case-control study, serum level of erythropoietin measured in 22 patients with Acute leukemia and 22 apparently healthy subjects using ELISA.

Statistical analysis was performed using SPSS 17.0 .

Results : There was a significant increment in level of erythropoietin in patients with acute leukemia compared to apparently healthy subjects (P < 0.001) independently to other parameters.

Conclusion: Erythropoietin concentrations may predict adverse outcomes, and their measurement may facilitate risk estimation in leukaemic patients.