Studies for Urokinase-type Plasminogen Activator Isolated from Camel Urine and its Effect on Lipid profile
Other Title(s)
دراسة لإنزيم اليوروكاينيزنوع البلازمنيوجين المنشط المعزول من بول الإبل و تأثيره على صورة الدهن الكاملة
Author
Source
Iraqi National Journal of Chemistry
Issue
Vol. 15, Issue 2 (30 Jun. 2015), pp.149-174, 26 p.
Publisher
University of Babylon College of Sciences
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
26
Main Subjects
Topics
Abstract EN
Urokinase-type plasminogen activator (uPA) was isolated from the camel urine.
One proteinous band had been isolated by gel filtration sephadex )G-100) and DEAE-Cellulose ion exchange from the proteinous supernatant produced by ammonium sulfate saturation (65%) after dialysis.
The apparent molecular weight of the isolated uPA using gel filtration chromatography (55246 + 350) Dalton and using SDS-PAGE giving two band (31002) and (24200) Dalton respectively.
Study the protective effect of uPA against atherosclerosis by measuring of lipid profile (Total cholesterol, HDL-C, LDL-C, VLDL-C and triglyceride) by intraperitoneal injection of 21 male albino white rats classified into 3 groups.
The rats were treated with 0.5 mg/kg/day (Group II) and 1mg/kg/day (Group III) of isolated uPA injected intraperitonealy for 5 successive days.
The results showed a significant reduction (p<0.05) in the levels of total cholesterol, LDL-C, VLDL-C and triglyceride in comparison with the normal group (Group I) and significantly elevated in HDL-C for the group II and group III in comparison with the group I.
Conclusion, the uPA isolated from camel urine, its may be has pharmacological role of heart protection against lipids.
American Psychological Association (APA)
Abd al-Hilali, Luayy. 2015. Studies for Urokinase-type Plasminogen Activator Isolated from Camel Urine and its Effect on Lipid profile. Iraqi National Journal of Chemistry،Vol. 15, no. 2, pp.149-174.
https://search.emarefa.net/detail/BIM-607310
Modern Language Association (MLA)
Abd al-Hilali, Luayy. Studies for Urokinase-type Plasminogen Activator Isolated from Camel Urine and its Effect on Lipid profile. Iraqi National Journal of Chemistry Vol. 15, no. 2 (2015), pp.149-174.
https://search.emarefa.net/detail/BIM-607310
American Medical Association (AMA)
Abd al-Hilali, Luayy. Studies for Urokinase-type Plasminogen Activator Isolated from Camel Urine and its Effect on Lipid profile. Iraqi National Journal of Chemistry. 2015. Vol. 15, no. 2, pp.149-174.
https://search.emarefa.net/detail/BIM-607310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 168-174
Record ID
BIM-607310