Patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism and liver damage in chronic hepatitis C Egyptian patients
Joint Authors
Maskawi, Amal M. H.
Mujahid, Ula
Badawi, Muhammad E. H.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 4 (31 Oct. 2015), pp.333-341, 9 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Hepatitis C virus (HCV) has been associated with high prevalence of steatosis and fibrosis.
The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domaincontaining protein 3 (PNPLA3) on the development of steatosis and fibrosis is not clarified for Egyptian patients with chronic hepatitis C (CHC).
The aim of the study was to assess whether the PNPLA3 I148M variant predisposes to steatosis, and to progressive liver damage, as evaluated fibrosis stage in Egyptian patients with CHC.
Subjects and methods: 218 CHC Egyptian patients were enrolled in the study, they were grouped by Ishak stage of fibrosis on liver biopsy into group I (fibrosis score 0 or 1; n 81), group II (fibrosis score 2 or 3; n 72) and group III (fibrosis score 4–6; n 65).
DNA was amplified by polymerase chain reaction.
Results : PNPLA3 genotype was not associated with metabolic parameters, including body mass index (BMI) and lipid levels, but the presence of G allele is associated with higher liver enzymes and viral loads levels.
The PNPLA3 G allele was associated with the severity (stage) of fibrosis (X2 =35.83, P = 0.000).
Steatosis was detected in 40.7 % of C allele carriers and 58.53% of G allele carriers.
The rs738409 G allele was significantly associated with steatosis in the overall CHC patients with different fibrotic stages (X2 = 6.023, P = 0.018) odds ratio (OR) and 95 % CI= 1.99 (1.146–3.47).
Conclusion : Steatosis and fibrosis severity seems to be PNPLA3 I148M regulated, independently to metabolic parameters but with significant association with viral loads and liver enzymes values in Egyptian patients with CHC.
American Psychological Association (APA)
Maskawi, Amal M. H.& Badawi, Muhammad E. H.& Mujahid, Ula. 2015. Patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism and liver damage in chronic hepatitis C Egyptian patients. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 4, pp.333-341.
https://search.emarefa.net/detail/BIM-608231
Modern Language Association (MLA)
Maskawi, Amal M. H.…[et al.]. Patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism and liver damage in chronic hepatitis C Egyptian patients. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 4 (2015), pp.333-341.
https://search.emarefa.net/detail/BIM-608231
American Medical Association (AMA)
Maskawi, Amal M. H.& Badawi, Muhammad E. H.& Mujahid, Ula. Patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism and liver damage in chronic hepatitis C Egyptian patients. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 4, pp.333-341.
https://search.emarefa.net/detail/BIM-608231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 340-341
Record ID
BIM-608231