Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity
Joint Authors
Abd al-Hamid, Inas Rafat
Abd al-Shahid, Azzah A.
Abu Shadi, Munis M.
Megawer, Amr Said
Yunus, Iman R.
Muhammad, Nadiyah A.
Sabri, Raniya N.
Source
Journal of the Arab Society for Medical Research
Issue
Vol. 10, Issue 1 (30 Jun. 2015), pp.27-31, 5 p.
Publisher
Arab Society for Medical Research
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background / aim Obesity is becoming an epidemic health problem.
Elevated cytokines and chemokines are prominent features in obesity, which play a main role in the development of other chronic diseases.
The aim of this study was to determine the serum levels of monocyte chemoattractant protein-1 (MCP-1), interlukin-6 (IL-6), and serum paraoxonase-1 (PON1) in childhood obesity.
Materials and methods The present study included 40 obese school-aged children (5–15 years) and 40 healthy children as controls.
The patients were presented to the outpatient clinic in National Institute of Nutrition.
MCP-1, IL-6, PON1, total cholesterol, and triglycerides were measured in all participants.
Results The mean serum levels of MCP-1, IL-6, and total cholesterol were signifi cantly higher in obese participants than in controls (P < 0.0001), whereas the PON1 was signifi cantly lower in obese participants than in controls (P < 0.0001).
MCP-1, IL-6, and serum cholesterol levels showed signifi cant positive correlation with BMI (P < 0.05), whereas PON1 showed a signifi cant negative correlation with BMI (P < 0.05).
Multiple regression analysis showed a strong association between PON1 activity and BMI (P < 0.0001).
Conclusion Childhood obesity is associated with increased serum MCP-1 and IL-6 and decreased PON1 and hypercholesterolemia suggesting an increase in adulthood disease risk.
Measuring serum MCP-1, IL-6, PON1 activity in obese children may be a good predictor for future chronic disease development and complications.
American Psychological Association (APA)
Abd al-Hamid, Inas Rafat& Abd al-Shahid, Azzah A.& Sabri, Raniya N.& Yunus, Iman R.& Abu Shadi, Munis M.& Muhammad, Nadiyah A.…[et al.]. 2015. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. Journal of the Arab Society for Medical Research،Vol. 10, no. 1, pp.27-31.
https://search.emarefa.net/detail/BIM-608475
Modern Language Association (MLA)
Yunus, Iman R.…[et al.]. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. Journal of the Arab Society for Medical Research Vol. 10, no. 1 (Jun. 2015), pp.27-31.
https://search.emarefa.net/detail/BIM-608475
American Medical Association (AMA)
Abd al-Hamid, Inas Rafat& Abd al-Shahid, Azzah A.& Sabri, Raniya N.& Yunus, Iman R.& Abu Shadi, Munis M.& Muhammad, Nadiyah A.…[et al.]. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. Journal of the Arab Society for Medical Research. 2015. Vol. 10, no. 1, pp.27-31.
https://search.emarefa.net/detail/BIM-608475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 30-31
Record ID
BIM-608475