Prevalence of peripheral arterial disease diagnosed by ankle brachial index among chronic kidney disease patients in a tertiary care unit

Abstract EN

The objective of this study is to determine the prevalence of peripheral vascular disease (PVD) in patients with chronic kidney disease (CKD).

Seventy-two patients with CKD stage 3 or above were included in this study.

Blood samples were taken from each patient to determine complete blood counts, serum albumin, electrolytes, lipid profile and blood sugar random/fasting.

The glomerular filtration rate (GFR) was estimated with the Cockcroft–Gault formula.

The ankle–brachial index (ABI) was determined to identify the presence of PVD.

A standardized Doppler ultrasound device was used.

ABI of <0.90 was considered diagnostic of PVD.

The mean age of the patients was 53.22  12.8 years.

Forty-six patients (63.9%) were male.

Twenty-five patients (34.7%) were in stage 3 CKD, 20 patients (27.8%) were in stage 4 CKD and 27 patients (37.5%) were in stage 5 CKD.

Twenty patients (27.8%) had an ABI <0.9 and hence had PVD.

Of these patients, 13 (18.1%) had mild to moderate PVD with ABI of 0.41–0.90 and seven (9.7%) had severe PVD with ABI of 0.00–0.40.

All the baseline parameters including systolic blood pressure (BP), diastolic BP, height, weight, body mass index, GFR, hemoglobin, total blood count, platelets, triglycerides, high-density lipoprotein, low-density lipoprotein and uric acid were not significantly different between patients with and without PVD (P >0.05).

However, the mean total cholesterol was significantly higher among patients with PVD.

The prevalence of PVD was significantly high in patients with stage 5 CKD (P <0.05).

PVD is frequent among patients with CKD based on the ABI as measured by Doppler ultrasound.