The effect of obesity and insulin resistance on liver enzymes in type2 diabetes mellitus
Other Title(s)
دراسة تأثير السمنة و مقاومة الأنسولين على أنزيمات الكبد في مرضى السكري النوع الثاني
Joint Authors
Salman, Ishraq Majid
al-Thamir, Bushra Faris Hasan Muhsin
Source
Issue
Vol. 12, Issue 3 (30 Sep. 2015), pp.536-545, 10 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
Diabetes mellitus (DM) has been defined as a clinical syndrome that is characterized by abnormal carbohydrate metabolism.
The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of different organs, especially the liver .This study was conducted to assess the effect obesity and insulin resistance on liver enzymes in diabetic Iraqi patients.
A comparative study of (90) Iraqi adults divided to three subgroup(30) obese ,(30) nonobese diabetic patients and(30)person had used as control.
The analysis included Liver enzyme ALP,ALT,AST,GGT ,Fasting Plasma Glucose (FBG) , Lipid Profile , Hemoglobin A1C , insulin and homeostasis model assessment of insulin resistance (HOMA IR) were measured.
Subjects were excluded from this study if they had liver disease, alcohol intake, medications for lowering lipid, insulin treatment, pregnant women and women taking contraceptive pills .
The study shows significantly higher of liver enzymes level ( gamma glutamyl transpeptidase (GGT), alkaline phosphatase, Aspartate Amino Transferase , Alanine Transaminase) in obese diabetic patients compared with non-obese diabetic patients and control subject and HOMA IR showed significantly higher in obese diabetic patients compared with non-obese with diabetic patients and control (P < 0.05).
The lipids level showed significantly higher in obese diabetic patients compared with non-obese diabetic patients and control.The HbA1c level showed higher significantly in obese diabetic patients compared with control and ther is a posative correlation between insulin and HOMA IR , ALP in obeses diabetic patients while there was negative correlation between ALT and cholesterol in obese group and with HbA1c in control group.
The liver enzymes level of(alkaline phosphatase, alanine transaminase, aspartate transaminase gama glutaminase transferase ) is significantly higher in obese diabetic patients than non –obese diabetic patients and control group , also There was posative correlation between ALP and HOMA IR while there was negative correlation between ALT and cholesterol in obese group and with HbA1c in control group .
American Psychological Association (APA)
Salman, Ishraq Majid& al-Thamir, Bushra Faris Hasan Muhsin. 2015. The effect of obesity and insulin resistance on liver enzymes in type2 diabetes mellitus. Baghdad Science Journal،Vol. 12, no. 3, pp.536-545.
https://search.emarefa.net/detail/BIM-609209
Modern Language Association (MLA)
Salman, Ishraq Majid& al-Thamir, Bushra Faris Hasan Muhsin. The effect of obesity and insulin resistance on liver enzymes in type2 diabetes mellitus. Baghdad Science Journal Vol. 12, no. 3 (2015), pp.536-545.
https://search.emarefa.net/detail/BIM-609209
American Medical Association (AMA)
Salman, Ishraq Majid& al-Thamir, Bushra Faris Hasan Muhsin. The effect of obesity and insulin resistance on liver enzymes in type2 diabetes mellitus. Baghdad Science Journal. 2015. Vol. 12, no. 3, pp.536-545.
https://search.emarefa.net/detail/BIM-609209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 543-544
Record ID
BIM-609209