A study of the effect of new cobalt (II) complex and cyclophosphamide drug on (GPT, ALP) activity by using in vivo system
Other Title(s)
دراسة تأثير معقد الكوبلت (II) الجديد و عقار السايكلوفوسفومايد على فعالية أنزيمي (ALP, GPT) باستخدام نظام داخل جسم الكائن الحي in vivo
Author
Source
Issue
Vol. 12, Issue 3 (30 Sep. 2015), pp.555-562, 8 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The present work involved a study the effect of cobalt(II) complex with formula [CoL(H2O)NO3] .4ETOH where L=Nitro [5-(P-nitro phenyl) -4-phenyl-1,2,4 traizole-3-dithiocarbamato hydrazide] aqua.
(4) Ethanol and anti-cancer drug - cyclophosphamide on specific activity of two liver enzymes (GPT,ALP) by utilizing an in vivo system in female mice.
On the enzymatic level an inhibition in the activity of GPT was noticed in different body organs such as liver, kidney and lung.
The inhibition was noticed in both test and cyclophosphamide drug (cp).
Mice were treated with three doses of cyclophosphamide (90,180, 250) μg/ mouse for three days.
The same doses were used for the cobalt (II) complex.
The liver shows the highest rate of(GPT) inhibition compared to other organs.
The ratio was about 90% at three doses of cobalt (II) complex, this ratio was similar to ratio inhibition of cyclophosphamide at the same doses.
On the contrary the enzyme ALP showed high activation in different organs such as liver, kidney and lung in both groups, test and cyclophosphamide drug (cp) at the three doses (90, 180, 250) μg /mouse.
The result showed the highest ratio of activation in the kidney comparable with other organs.
The maximum activation of cobalt(II) complex was about 1198% at a concentration 180μg/mouse.There are significant differences(P<0.05) for two treatment when the concentration was increased.
American Psychological Association (APA)
Murtada, Janan Husayn. 2015. A study of the effect of new cobalt (II) complex and cyclophosphamide drug on (GPT, ALP) activity by using in vivo system. Baghdad Science Journal،Vol. 12, no. 3, pp.555-562.
https://search.emarefa.net/detail/BIM-609232
Modern Language Association (MLA)
Murtada, Janan Husayn. A study of the effect of new cobalt (II) complex and cyclophosphamide drug on (GPT, ALP) activity by using in vivo system. Baghdad Science Journal Vol. 12, no. 3 (2015), pp.555-562.
https://search.emarefa.net/detail/BIM-609232
American Medical Association (AMA)
Murtada, Janan Husayn. A study of the effect of new cobalt (II) complex and cyclophosphamide drug on (GPT, ALP) activity by using in vivo system. Baghdad Science Journal. 2015. Vol. 12, no. 3, pp.555-562.
https://search.emarefa.net/detail/BIM-609232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 560-561
Record ID
BIM-609232