Assessment of renal functional reserve by dynamic renal function testing
Joint Authors
Zitta, Sabine
Holzer, Herwig
Estelberger, Willibald
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 13, Issue 3 (30 Jun. 2002), pp.241-249, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2002-06-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Renal clearances of suitable clearance markers such as inulin and p-aminohippurate, determined before and after protein load, have been used for a long time to determine glomerular filtration rate (GFR), renal blood-flow, renal functional reserve as well as renal vascular resistance.
Despite this long history, inconsistent results were achieved in determining renal functional reserve after protein ingestion or amino acids infusion.
Most authors found acute 'blunted increases' in GFR after dietary stresses, whereas others found acute decreases.
In hypertensive patients showing hyper filtration, a contradictory situation was observed ; the traditionally observed 'blunted increase' in GFR and increase in the intraglomerular pressure were neither accompanied by a change in albumin excretion nor by an expected dynamic GFR response after administration of angiotensin converting enzyme (ACE)-inhibitors.
We are of the opinion that the traditional clinical methods for assessing acutely provoked changes in renal function have been inappropriate and that an approach based on the two-compartment model of pharmacokinetics is more adequate for studying dynamic clearance changes within clinically feasible time horizons.
Such test evaluations performed in patients within a washout period, and after long-term treatment with various drugs enable one to assess the efficacy of the therapeutic regimens especially in patients showing apparently normal or increased baseline clearances in hyper filtering kidneys.
American Psychological Association (APA)
Zitta, Sabine& Holzer, Herwig& Estelberger, Willibald. 2002. Assessment of renal functional reserve by dynamic renal function testing. Saudi Journal of Kidney Diseases and Transplantation،Vol. 13, no. 3, pp.241-249.
https://search.emarefa.net/detail/BIM-61149
Modern Language Association (MLA)
Holzer, Herwig…[et al.]. Assessment of renal functional reserve by dynamic renal function testing. Saudi Journal of Kidney Diseases and Transplantation Vol. 13, no. 3 (Jun. 2002), pp.241-249.
https://search.emarefa.net/detail/BIM-61149
American Medical Association (AMA)
Zitta, Sabine& Holzer, Herwig& Estelberger, Willibald. Assessment of renal functional reserve by dynamic renal function testing. Saudi Journal of Kidney Diseases and Transplantation. 2002. Vol. 13, no. 3, pp.241-249.
https://search.emarefa.net/detail/BIM-61149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 248-249
Record ID
BIM-61149