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The role of topical application of bone morphogenetic protein 7 (BMP7) on bone healing on rabbits (immunohistochemical study on TGF-β 3 and IGF-1R)
Joint Authors
Gharib, Rabab Ikram
al-Tamimi, Iman Isa
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 27, Issue 3 (30 Sep. 2015), pp.70-78, 9 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
Background : Bone is essentially a highly vascular, living, constantly changing mineralized connective tissue.
It is remarkable for its hardness, resilience and regenerative capacity, as well as its characteristic growth mechanisms.
This study aimed to : 1.
To evaluate the effect of bone morphogenetic protein7 (BMP7) on bone healing in artificially created intrabony defect in rabbits upper diastema, histologically.
2.
To study the immunohistochemical expression of TGF-β3 and IGF-1R as bone formation markers in experimental and control groups during bone healing.
Material and method: Forty male rabbits, was used in this study, 8 rabbits for each healing interval (3 days, 1,2 ,4 and 6 weeks).
In each rabbit two bone holes were created on the right and left sides of the maxilla.BMP7 was applied to the bone hole in the left side while bone hole in the right left for normal healing.
Routine processing and sectioning technique performed for histological evaluation.
Immunohistochemical analysis utilized to localize the expression of TGF-β3 and IGF-1R in experimental and control groups for all animals.
Results : Histological findings indicated that bone defect coated with BMP7 illustrated an early bone formation, mineralization and maturation in comparison to control group.
Immunohistochemical findings revealed high positive expression for TGF-B3 and IGF-1R in experimental in comparison to control group.
Conclusion : The study concluded that BMP7 protein enhance bone healing and maturation, also it regulate the expression of TGF-B3 and IGF1R in bone.
American Psychological Association (APA)
Gharib, Rabab Ikram& al-Tamimi, Iman Isa. 2015. The role of topical application of bone morphogenetic protein 7 (BMP7) on bone healing on rabbits (immunohistochemical study on TGF-β 3 and IGF-1R). Journal of Baghdad College of Dentistry،Vol. 27, no. 3, pp.70-78.
https://search.emarefa.net/detail/BIM-611494
Modern Language Association (MLA)
Gharib, Rabab Ikram& al-Tamimi, Iman Isa. The role of topical application of bone morphogenetic protein 7 (BMP7) on bone healing on rabbits (immunohistochemical study on TGF-β 3 and IGF-1R). Journal of Baghdad College of Dentistry Vol. 27, no. 3 (Sep. 2015), pp.70-78.
https://search.emarefa.net/detail/BIM-611494
American Medical Association (AMA)
Gharib, Rabab Ikram& al-Tamimi, Iman Isa. The role of topical application of bone morphogenetic protein 7 (BMP7) on bone healing on rabbits (immunohistochemical study on TGF-β 3 and IGF-1R). Journal of Baghdad College of Dentistry. 2015. Vol. 27, no. 3, pp.70-78.
https://search.emarefa.net/detail/BIM-611494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 78
Record ID
BIM-611494