Anti-inflammatory effects of herbal-derived factors are mediated by down regulation of pro-inflammatory cytokines
Other Title(s)
تحقق فعالية النباتات المضادة للالتهابات بواسطة تأثيرها على السيتوكنات (cytokines) الالتهابية و المضادة للالتهاب
Joint Authors
Hadiyah, Bahaa
Said, Umar
Masalihah, Mahmud
Abu al-Farkh, Bashir
Abu Mukh, Ala
Sad, Bashshar
Source
Jami'a : Journal in Educational and Social Sciences
Issue
Vol. 2010, Issue 14 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
أكاديمية القاسمي مركز الأبحاث التربوية و الاجتماعية
Publication Date
2010-12-31
Country of Publication
Palestine (West Bank)
No. of Pages
12
Main Subjects
Topics
Abstract EN
The aim of the present in vitro study is to evaluate the role of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in the observed anti-inflammatory effects of Hypericum triquetrifolium and Peganum harmale.
Therefore, water extracts from the aerial parts of the two plants were tested for their anti-inflammatory effects in vitro using cells from the human monocyte cell line THP-1.
Anti-inflammatory effects were assessed by measuring the levels of secretory proteins and mRNA of TNF-α and IL-6 production of LPS-activated THP- 1 cells.
Cells were treated with 5μg lipopolyssacharide/ml (LPS) in the absence and presence of increasing concentrations of plant extracts.
During the entire experimental period, we used plant extracts concentrations (up to 250μg/ml) that had no cytotoxicity as measured in MTT assay.
Hypericum triquetrifolium extracts totally reduced the LPS induced TNF-α expression and secretion.
Peganum harmale extracts inhibited the IL-6 production in a dose dependent manner reaching the control levels of untreated cells at a concentration of 125 μg/ml.
These results demonstrate that the anti-inflammatory effects of the two plants are mediated through the inhibition of the pro-inflammatory cytokines TNF-α and IL-6.
American Psychological Association (APA)
Hadiyah, Bahaa& Said, Umar& Masalihah, Mahmud& Abu al-Farkh, Bashir& Abu Mukh, Ala& Sad, Bashshar. 2010. Anti-inflammatory effects of herbal-derived factors are mediated by down regulation of pro-inflammatory cytokines. Jami'a : Journal in Educational and Social Sciences،Vol. 2010, no. 14, pp.1-12.
https://search.emarefa.net/detail/BIM-612916
Modern Language Association (MLA)
Hadiyah, Bahaa…[et al.]. Anti-inflammatory effects of herbal-derived factors are mediated by down regulation of pro-inflammatory cytokines. Jami'a : Journal in Educational and Social Sciences No. 14 (Dec. 2010), pp.1-12.
https://search.emarefa.net/detail/BIM-612916
American Medical Association (AMA)
Hadiyah, Bahaa& Said, Umar& Masalihah, Mahmud& Abu al-Farkh, Bashir& Abu Mukh, Ala& Sad, Bashshar. Anti-inflammatory effects of herbal-derived factors are mediated by down regulation of pro-inflammatory cytokines. Jami'a : Journal in Educational and Social Sciences. 2010. Vol. 2010, no. 14, pp.1-12.
https://search.emarefa.net/detail/BIM-612916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-11
Record ID
BIM-612916