Treatment of perniosis with oral tadalafil, pentoxifylline or prednisolone : a therapeutic comparative study
Joint Authors
Sharqiyah, Khalifa E.
Salman, Husam Ali
al-Nuaymi, Adil A.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 57, Issue 3 (30 Sep. 2015), pp.210-213, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : perniosis is a common dermatological problem.
Different modalities of treatment are available with conflicting results and no single effective therapy is universally accepted.
Objective : To evaluate the effectiveness of oral tadalafil and compare it with pentoxyfylline or prednisolone in treatment of perniosis Patients and methods: This was a therapeutic comparative trial conducted in the department of Dermatology, Baghdad Teaching hospital, Baghdad, Iraq between November 2011 and March 2014.
Fifty eight patients with perniosis were enrolled in this study, and divided into 3 groups.
Group (A) comprised 19 patients who received oral tadalafil (5 mg once daily); group (B) comprised 18 patients who received pentoxifylline tablet (400 mg three times daily) and group (C) included 21 patients who received prednisolone 15 mg twice daily.
The treatment duration was 2 weeks.
All patients did not receive any treatment before the study.
A severity score was proposed taken in consideration the number of finger/ toes, type of lesion, coldness, cyanosis and itching Results: Forty seven patients completed the study.
Their ages ranged from 13-43 with a mean ± SD of 22.38 ±6.99 years.
Thirty three patients were females (70.21%) and 14 were males (29.79%).
The percentage of improvement was 50.65, 44.16 and 31.51% for the groups A, B and C respectively.
Conclusion: Tadalafil has a superior effect over pentoxyfylline.
The latter has a better effect than prednisolone.
American Psychological Association (APA)
Sharqiyah, Khalifa E.& Salman, Husam Ali& al-Nuaymi, Adil A.. 2015. Treatment of perniosis with oral tadalafil, pentoxifylline or prednisolone : a therapeutic comparative study. Journal of the Faculty of Medicine Baghdad،Vol. 57, no. 3, pp.210-213.
https://search.emarefa.net/detail/BIM-616895
Modern Language Association (MLA)
Sharqiyah, Khalifa E.…[et al.]. Treatment of perniosis with oral tadalafil, pentoxifylline or prednisolone : a therapeutic comparative study. Journal of the Faculty of Medicine Baghdad Vol. 57, no. 3 (2015), pp.210-213.
https://search.emarefa.net/detail/BIM-616895
American Medical Association (AMA)
Sharqiyah, Khalifa E.& Salman, Husam Ali& al-Nuaymi, Adil A.. Treatment of perniosis with oral tadalafil, pentoxifylline or prednisolone : a therapeutic comparative study. Journal of the Faculty of Medicine Baghdad. 2015. Vol. 57, no. 3, pp.210-213.
https://search.emarefa.net/detail/BIM-616895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 213
Record ID
BIM-616895