Development of anti-bodies against infliximab in Iraqi patients with rheumatoid arthritis
Joint Authors
al-Karkhi, Muhammad A.
al-Mahdi, Batul M.
Abd al-Ilah, Layth
al-Ani, Muhammad M.
Jasim, Nizar A.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 57, Issue 3 (30 Sep. 2015), pp.241-243, 3 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
3
Main Subjects
Topics
Abstract EN
Background: Rheumatoid arthritis is a common chronic and destructive autoimmune arthropathy .Treatment with infliximab gives great improvement to a large numbers of patients with RA ,however, in some patients after prolonged treatment infliximab can induce anti-infliximab antibodies formation and result to loss of infliximab efficacy and active persistent disease.
Objective: to investigate the frequency of anti-infliximab antibodies in Iraqi patients with rheumatoid arthritis.
Patients and methods: fifty Iraqi RA patients(36 females and 14 males) compared with 50 control( 25 healthy control and 25 case control (patients with RA on other treatment) ) were included in this study from begging of March 2014 till end of September 2014.All patients were diagnosed by full history, complete clinical examination and laboratory test.
Anti-infliximab antibodies were meatured using enzyme-linked immunosorbent assay in serum of Iraqi patients with RA treated with infliximab more than 3 months duration.
Results: Antibodies to infliximab were detected in 35(70%) Iraqi RA patients , while the patients without detectable antibodies against infliximab were 15(30%),also there were no anti-infliximab antibodies in the control groups.
Conclusion: In this study, nearly three quarter of the Iraqi RA patients treated with infliximab developed anti-infliximab antibodies.
American Psychological Association (APA)
al-Karkhi, Muhammad A.& al-Ani, Muhammad M.& Jasim, Nizar A.& al-Mahdi, Batul M.& Abd al-Ilah, Layth. 2015. Development of anti-bodies against infliximab in Iraqi patients with rheumatoid arthritis. Journal of the Faculty of Medicine Baghdad،Vol. 57, no. 3, pp.241-243.
https://search.emarefa.net/detail/BIM-617013
Modern Language Association (MLA)
al-Karkhi, Muhammad A.…[et al.]. Development of anti-bodies against infliximab in Iraqi patients with rheumatoid arthritis. Journal of the Faculty of Medicine Baghdad Vol. 57, no. 3 (2015), pp.241-243.
https://search.emarefa.net/detail/BIM-617013
American Medical Association (AMA)
al-Karkhi, Muhammad A.& al-Ani, Muhammad M.& Jasim, Nizar A.& al-Mahdi, Batul M.& Abd al-Ilah, Layth. Development of anti-bodies against infliximab in Iraqi patients with rheumatoid arthritis. Journal of the Faculty of Medicine Baghdad. 2015. Vol. 57, no. 3, pp.241-243.
https://search.emarefa.net/detail/BIM-617013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 243
Record ID
BIM-617013