Serum levels of total IgE and IgE binding factor (soluble cd23)‎ in atopic disorders

Abstract EN

CD23, the low affinity receptor for IgE (FC? R II), functions as a multifunctional regulator of immune system and IgE synthesis, in part, by producing an IgE binding factor (soluble CD23).

Objectives: To evaluate the serum levels of total IgE and soluble CD23 (sCD23) in the atopic patients and to determine whether there is any correlation between these markers.

Method: Forty-five adult atopic subjects (allergic rhinitis 17, allergic asthma 17 and atopi dermatitis 11) with positive skin prick test to common allergens and positive family history of atopy were entrolled in a case-control study.

Serum levels of total IgE and sCd23 of these subjects were measured by ELISA controls.

Results: Mean age and sex ratio were similar among study groups.

Mean serum levels of sCD23 in atopic groups (5.12±3.9ng/ml) were significantly higher than control group (0.2ng/ml) (P<0.01).

Mean total IgE level in atopic groups and control group were 388±204 IU/ml, 43±40 IU/ml respectively.

Atopic subjects had significantly higher IgE level (P<0.01).

There were no correlations between serum levels of total IgE and sCD23.

Conclusion: sCD23 maybe a good atopy prediction marker.