A study on etiologies of hirsutism and screening for late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Abstract EN

Eighty hirsute women (Ferry man and Gallwey score ³ 8) who referred to the endocrinology clinics of Shiraz University and ten control normal nonhirsute women were assessed in this study. Baseline 17-hydroxyorogesterone (17 OH PG), cortisol, stimulated 17-hydroxyprogesterone and corti801 after 30 minutes of cosyntropin (short acting ACTH) injection were measured for screening of late-onset congenital adrenal hyperplasis (LOCAH) during follicular phase.

Baseline testosterone, Luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) prolactin (PRI), and dihydroepian drosterone sulfate (DHEA-So4) were also measured. The ovaries were visualized in 42 patients by sonography, of the 80 hirsute women, 3 had late-onset CAH due to 21-Hydroxylase (21 OH) deficiency (3.8 %), 43 women diagnosed as having Polycystic ovary syndrome (53.7 %) and 34 women diagnosed as having idiopathic hirsutism (42.5 %).