Synthesis of some 1, 3, 4- oxadizole derivatives from naproxen and acetyl chloride

Abstract EN

A seriers of 1, 3, 4-oxadiazol-2-thion were synthesized by the reaction of naproxen (or acetyl) amino acid hydrazides (glycine, valine, leucine, isoleucine and tyrosine) with carbon disulphide in alkaline medium.

The reaction of naproxen (or acetyl) amino acid hydrazides were treated with p-chloro benzaldehyde to give hydrazone, the hydrazones were then cyclized with lead dioxide to give 1, 3, 4-oxadiazol-2-aryl.

Naproxen amino acid esters were treated with ammonia gas to give naproxen amino acid amids.

The synthesized compounds were characterized by physical and spectral analysis.