Formulation and in-vitro evaluation of theophylline sustained release matrix tablets using hot melt granulation technique
Other Title(s)
تصييغ و تقييم حبوب الماتريكس للثيوفيلين طويلة الأمد خارج الجسم و المصنعة بطريقة صهر الحبيبات
Dissertant
al-Tubassi, Hanin Abd al-Hamid
Thesis advisor
al-Mulla, Muayyad Ahmad Shihab
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2015
English Abstract
An oral sustained release matrix tablet of Theophylline HCl for up to 8h was developed using a binary mixture of polyehylline glycol (PEG 4000 or 6000) and polyvinyl acetate (PVAc) by hot melt granulation technique.
Technological characterization (mean weight, diameter, thickness, hardness and swelling) was carried out and in vitro drug release behaviour was measured using the SUP paddle apparatus.
The effect varying the PEG-PVAc ratio, as well as the drug-polymer matrix ratio, was evaluated.
The results of controlled release tests showed that the amount of drug release is decreased with increasing the proportion of PVAc.
Moreover, the release rate of drug decreased as the amount of drug loaded in the matrix increased.
DSC and FTIR studies indicated the apsence of any significant chemical interaction between the drug the the polymers.
Data fitted to Korsmeyers- Peppas equation indicated an Anomalous non-fickian transport suggesting that the drug release is mainly diffusion- erosion mechanism
Main Subjects
Topics
No. of Pages
118
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental and methods.
Chapter Three : Result and discussion.
Chapter Four : Conclusion.
References.
American Psychological Association (APA)
al-Tubassi, Hanin Abd al-Hamid. (2015). Formulation and in-vitro evaluation of theophylline sustained release matrix tablets using hot melt granulation technique. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-621314
Modern Language Association (MLA)
al-Tubassi, Hanin Abd al-Hamid. Formulation and in-vitro evaluation of theophylline sustained release matrix tablets using hot melt granulation technique. (Master's theses Theses and Dissertations Master). Isra University. (2015).
https://search.emarefa.net/detail/BIM-621314
American Medical Association (AMA)
al-Tubassi, Hanin Abd al-Hamid. (2015). Formulation and in-vitro evaluation of theophylline sustained release matrix tablets using hot melt granulation technique. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-621314
Language
English
Data Type
Arab Theses
Record ID
BIM-621314
