Formulation and in-vitro evaluation of ibuprofen release rate from PEG PVAc matrix tablet and the effect of different formulation variables
Other Title(s)
تقييم الحبوب المصنعة من كزيج الأيبوبروفين البولي ايثلين جلايكول البولي فينيل اسيتيت بطريقة الماتركس : و تأثير مختلف التحضيرات على معدل تحرر الدواء خارج الجسم
Dissertant
Sulayman, Sarah Muhammad Hamid
Thesis advisor
al-Mulla, Muayyad Ahmad Shihab
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2015
English Abstract
This study reports the development and evaluation of controlled release Ibuprofen-matrix tablets.
Matrix tablets weighing 600mg were fabricated by hot melt granulation method and direct compression of the granules containing Ibuprofen (200 mg) with PEG & PVAc the tablets were evaluated for physical properties, in-vitro swelling behavior, in-vitro release studies and compatibility studies.
The rate release of Ibuprofen was dependent on concentration of PVAc in the formulation.
Varying PVAc concentration from 2 to 10% in the formulation revealed that in 8hrs, tablets containing 10% w/w PVAc released about 70% of the initial Ibuprofen content compared to almost 98% of Ibuprofen released from tablets containing 2% w/w PVAc.
Results of in-vitro swelling study indicate that ibuprofen with PEG6000/PVAc 8% exhibited a considerable swelling index.
The results of differential scanning calorimetry (DSC) studies showed that Ibuprofen formed a simple mixture with PEG.
xxii Results of Fourier transform infrared spectroscopy (FTIR) study revealed that the principle peaks of drug are intact in the formulations.
Drug excipients interactions were not observed and this indicates that the drug was compatible with the formulation components.
Follows analysis of release mechanism using various models available, release of Ibuprofen from matrix tablets was dominated by polymers diffusion-controlled mechanism at least for the first 5hrs.
Thereafter, the release mechanisms become more complicated due to change of tablet integrity, such as erosion of polymer matrix.
Therefore, data fitted to Korsmeyers – Peppas equation indicated an Anomalous non fickian transport suggesting that the drug release is mainly diffusion- erosion mechanism.
In conclusion, controlled release Ibuprofen matrix tablets with desired drug release rate can be fabricated by various formulation variables.
The drug release mechanism was found to be anomalous or non-fickian type and controlled by diffusion through the swollen matrix.
The effect of experimental variables are discussed in relation to diffusional- models
Main Subjects
No. of Pages
134
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental and methods.
Chapter Three : Result and discussion.
Chapter Four : Conclusions.
References.
American Psychological Association (APA)
Sulayman, Sarah Muhammad Hamid. (2015). Formulation and in-vitro evaluation of ibuprofen release rate from PEG PVAc matrix tablet and the effect of different formulation variables. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-621350
Modern Language Association (MLA)
Sulayman, Sarah Muhammad Hamid. Formulation and in-vitro evaluation of ibuprofen release rate from PEG PVAc matrix tablet and the effect of different formulation variables. (Master's theses Theses and Dissertations Master). Isra University. (2015).
https://search.emarefa.net/detail/BIM-621350
American Medical Association (AMA)
Sulayman, Sarah Muhammad Hamid. (2015). Formulation and in-vitro evaluation of ibuprofen release rate from PEG PVAc matrix tablet and the effect of different formulation variables. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-621350
Language
English
Data Type
Arab Theses
Record ID
BIM-621350
