Synthesis of some substituted 1,3,4-oxadiazoles from hydrazones
Joint Authors
Dawud, Khalid M.
Ali, Amal N.
Ahmad, A. Kh.
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 22, Issue 3 (30 Sep. 2009), pp.11-18, 8 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2009-09-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
In this paper the synthesis of some 2-(3-pyridyl)-5-aryl-1,3,4-oxadiazoles from hydrazones is reported.
Nicotinic acid was converted to ethyl nicotinate (1) by its reaction with thionyl chloride and the resultant acid chloride was treated with absolute ethanol, the ethyl nicotinates was treated with hydrazine hydrate in ethanol to give the corresponding acid hydrazide (2).
The acid hydrazide was treated with benzaldehyde or substituted benzaldehyde to give the hydrazones (3-8).
The hydrazones were cyclized to 2-(3-pyridyl)-5-aryl-1,3,4-oxadiazoles (4-14) by their reaction with lead oxide.
The structure of the synthesised compounds were confirmed by physical and spectral methods.
American Psychological Association (APA)
Dawud, Khalid M.& Ahmad, A. Kh.& Ali, Amal N.. 2009. Synthesis of some substituted 1,3,4-oxadiazoles from hydrazones. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 22, no. 3, pp.11-18.
https://search.emarefa.net/detail/BIM-621372
Modern Language Association (MLA)
Dawud, Khalid M.…[et al.]. Synthesis of some substituted 1,3,4-oxadiazoles from hydrazones. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 22, no. 3 (Sep. 2009), pp.11-18.
https://search.emarefa.net/detail/BIM-621372
American Medical Association (AMA)
Dawud, Khalid M.& Ahmad, A. Kh.& Ali, Amal N.. Synthesis of some substituted 1,3,4-oxadiazoles from hydrazones. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2009. Vol. 22, no. 3, pp.11-18.
https://search.emarefa.net/detail/BIM-621372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 17-18
Record ID
BIM-621372