Spectrophotometric determination of sulphamethoxazole via charge transfer complex formation reaction
Joint Authors
al-Anzi, Muhammad Suud
al-Sabhah, Thiya Najm
al-Ghabsha, Thabit S.
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 26, Issue 4 (31 Dec. 2013), pp.56-67, 12 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract AR
تــم وصــف طریقــة طیفیــة بــسیطة و حــساسة لتقــدیر السلفامیثوكــسازول بهیئتــه النقیــة و فــي مستحضراته الصیدلانیة.
تعتمد الطریقة على تفاعـل السلفامیثوكـسازول كمـادة مانحـة للالكترونـات مع أورثو -كلورانیل كمادة مستقبلة للالكترونـات لتكـوین معقـد الـشحنة المنتقلـة ذي اللـون البنفـسجي الذي یمتلك أقصى امتصاص عند الطـول المـوجي 539 نـانومیتر.
لقـد وجـد عنـد الظـروف المثلـى أن قـــانون بیـــر ینطبـــق بحـــدود 2-60مـــایكروغرام/ مللتــــر بامتـــصاصیة مولاریـــة 3.675 ×10 لتــر/ مــول.
ســم.
كمــا وجــد حــد الكــشف و الحــد الكمــي 0.371 و 1.236 مــایكرو غرام/ مللتــر علــى التـوالي.
كـان معـدل نـسبة الاسـترجاعیة 100.95 % و الانحـراف القیاسـي النـسبي ≤ 1.06 %.
تـم دراسـة طبیعـة المعقـد و میكانیكیـة التفاعـل.
طبقـت الطریقـة بنجـاح فـي تقـدیر السلفامیثوكـسازول فـي مستحضراته الصیدلانیة على شكل أقراص و شراب بدقة و توافق جیدین.
Abstract EN
A simple and sensitive spectrophotometric method for the determination of sulphamethoxazole in pure as well as in dosage form is described.
The method is based on the reaction of sulphamethoxazole as electron donor with o-chloranil as electron acceptor to form violet colored charge transfer complex having maximum absorption band at 539 nm.
Under the optimized reaction conditions, Beer’s law was obeyed in the- range of 2-60 μg ml-1 with molar absorptivity 3.675×103 L mol−1cm−1.
The limits of detection (LOD) and limit of quantitation (LOQ) were 0.371 and 1.236 μg ml-1 respectively.
The accuracy and precision of the method were satisfactory; the average recovery % was 100.95 % and values of relative standard deviations ≤1.06 %.
The stoichiometry of the reaction was studied, and the reaction mechanism was postulated.
The proposed method was successfully applied to the determination of sulphamethoxazole in its pharmaceutical tablets and syrup with good accuracy and precisions.
American Psychological Association (APA)
al-Ghabsha, Thabit S.& al-Sabhah, Thiya Najm& al-Anzi, Muhammad Suud. 2013. Spectrophotometric determination of sulphamethoxazole via charge transfer complex formation reaction. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 26, no. 4, pp.56-67.
https://search.emarefa.net/detail/BIM-621677
Modern Language Association (MLA)
al-Ghabsha, Thabit S.…[et al.]. Spectrophotometric determination of sulphamethoxazole via charge transfer complex formation reaction. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 26, no. 4 (Dec. 2013), pp.56-67.
https://search.emarefa.net/detail/BIM-621677
American Medical Association (AMA)
al-Ghabsha, Thabit S.& al-Sabhah, Thiya Najm& al-Anzi, Muhammad Suud. Spectrophotometric determination of sulphamethoxazole via charge transfer complex formation reaction. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2013. Vol. 26, no. 4, pp.56-67.
https://search.emarefa.net/detail/BIM-621677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 66-67
Record ID
BIM-621677