Synthesis of some heterocyclic compounds via cyclization of imidoyl chloride

Abstract EN

Some substituted pyrazoline 3(a-e) were prepared from the reaction of acrelonitril with some substituted imidoyl chloride 2(a-e) (which prepared from substituted - N – phenyl hydrazide 1(a-e) on treatment with phosphorous penta chloride).

Compounds 3(a–e) were then transformed into the corresponding imidate hydrochloride 4(a–e) during the reaction with hydrochloric acid in absolute ethanol.

Compounds 4(a–e) were allowed to react with either p – nitro phenyl hydrazide, sodium azid or ethylene diamine giving the corresponding 1,2,3 – substituted triazoles 5(a–e), 1,2,3,4- substituted tetrazoles 6(d,e) and imidazoles 7(d,e) respectively.